6PSX
 
 | | Cryo-EM structure of S. cerevisiae Drs2p-Cdc50p in the PI4P-activated form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cell division control protein 50, ... | | 著者 | Bai, L, Li, H. | | 登録日 | 2019-07-14 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nat Commun, 10, 2019
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6PUU
 | | Human TRPM2 bound to 8-Br-cADPR and calcium | | 分子名称: | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6Q21
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6PUO
 | | Human TRPM2 in the apo state | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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2W2V
 | | Rac2 (G12V) in complex with GTPgS | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 | | 著者 | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | 登録日 | 2008-11-04 | | 公開日 | 2009-05-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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2W2T
 | | Rac2 (G12V) in complex with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 | | 著者 | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | 登録日 | 2008-11-04 | | 公開日 | 2009-05-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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2W2X
 | | Complex of Rac2 and PLCg2 spPH Domain | | 分子名称: | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | | 登録日 | 2008-11-04 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
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2LHI
 | | Solution structure of Ca2+/CNA1 peptide-bound yCaM | | 分子名称: | CALCIUM ION, Calmodulin,Serine/threonine-protein phosphatase 2B catalytic subunit A1 | | 著者 | Ogura, K, Takahashi, K, Kobashigawa, Y, Yoshida, R, Itoh, H, Yazawa, M, Inagaki, F. | | 登録日 | 2011-08-10 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of yeast Saccharomyces cerevisiae calmodulin in calcium- and target peptide-bound states reveal similarities and differences to vertebrate calmodulin.
Genes Cells, 17, 2012
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5M6C
 | | CRYSTAL STRUCTURE OF T71N MUTANT OF HUMAN HIPPOCALCIN | | 分子名称: | CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin | | 著者 | Helassa, N, Antonyuk, S.V, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. | | 登録日 | 2016-10-24 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Hum. Mol. Genet., 26, 2017
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1WJO
 | | Solution structure of the forth CH domain from human plastin 3 T-isoform | | 分子名称: | T-plastin | | 著者 | Tomizawa, T, Kigawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2004-05-29 | | 公開日 | 2004-11-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the forth CH domain from human plastin 3 T-isoform
To be Published
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5MY3
 | | Crystal structure of the RhoGAP domain of Rgd1p at 2.19 Angstroms resolution | | 分子名称: | RHO GTPase-activating protein RGD1 | | 著者 | Martinez, D.M, d'Estaintot, B.L, Granier, T, Hugues, M, Odaert, B, Gallois, B, Doignon, F. | | 登録日 | 2017-01-25 | | 公開日 | 2018-01-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structural evidence of a phosphoinositide-binding site in the Rgd1-RhoGAP domain.
Biochem. J., 474, 2017
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1X86
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2MZN
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5NC7
 | | ENAH EVH1 in complex with Ac-WPPPPTEDEL-NH2 | | 分子名称: | ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization, Protein enabled homolog | | 著者 | Barone, M, Roske, Y. | | 登録日 | 2017-03-03 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5NXD
 | | LIM Domain Kinase 2 (LIMK2) In Complex With TH-300 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, LIM domain kinase 2 | | 著者 | Mathea, S, Salah, E, Hanke, T, Newman, J.A, Oerum, S, Wang, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Knapp, S. | | 登録日 | 2017-05-10 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | LIM Domain Kinase 2 (LIMK2)In Complex With TH-300
To Be Published
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5OCG
 | | Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GTPase KRas, ... | | 著者 | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | | 登録日 | 2017-06-30 | | 公開日 | 2018-08-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
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5ND0
 | | ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-TEDEL-NH2 | | 分子名称: | 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, NITRATE ION, Protein enabled homolog, ... | | 著者 | Barone, M, Roske, Y. | | 登録日 | 2017-03-07 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5NC2
 | | ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPPTEDEL-NH2 | | 分子名称: | Ac-[2-Cl-F]PPPPTEDEL-NH2, NITRATE ION, Protein enabled homolog, ... | | 著者 | Barone, M, Roske, Y. | | 登録日 | 2017-03-03 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5NXC
 | | LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736 | | 分子名称: | (2~{R})-2-azanyl-2-cyclohexyl-~{N}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide, LIM domain kinase 1 | | 著者 | Mathea, S, Salah, E, Pike, A.C.W, Bushell, S, Carpenter, E.P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Knapp, S. | | 登録日 | 2017-05-10 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | LIM Domain Kinase (LIMK1) In Complex With PF-00477736
To Be Published
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5OB0
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5OB2
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5O8K
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5OAV
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2OYC
 | | Crystal structure of human pyridoxal phosphate phosphatase | | 分子名称: | Pyridoxal phosphate phosphatase, SODIUM ION, TUNGSTATE(VI)ION | | 著者 | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2007-02-21 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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2P69
 | | Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP | | 分子名称: | CALCIUM ION, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate phosphatase | | 著者 | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2007-03-16 | | 公開日 | 2007-04-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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