5NC7

ENAH EVH1 in complex with Ac-WPPPPTEDEL-NH2

Summary for 5NC7

• Entry DOI: 10.2210/pdb5nc7/pdb
• Descriptor: Protein enabled homolog, ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization (3 entities in total)
• Functional Keywords: proline-rich motif, acta, protein-protein interaction, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 60147.55

Authors

Barone, M.,Roske, Y. (deposition date: 2017-03-03, release date: 2018-03-21, Last modification date: 2024-01-31)

• Primary citation: Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R.; Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.; Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020; PubMed: 33184177; DOI: 10.1073/pnas.2007213117

Experimental method

X-RAY DIFFRACTION (2.7 Å)