PDB: 143 件ウェブページステータス検索Chemie searchBIRD

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8H34	Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex 分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-07 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (7.99 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H33	Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex 分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-07 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (7.86 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H3Q	Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex 分子名称: Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-09 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.76 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H3A	Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-08 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (7.51 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H3F	Cryo-EM Structure of the KBTBD2-CRL3-CSN complex 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-08 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (6.73 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
7Z8B	Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation 分子名称: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ... 著者 Hopf, L.V.M, Schulman, B.A. 登録日 2022-03-17 公開日 2022-08-24 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat.Struct.Mol.Biol., 29, 2022
6R8Z	Cryo-EM structure of NCP_THF2(-1)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R90	Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R91	Cryo-EM structure of NCP_THF2(-3)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R92	Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B 分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R8Y	Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
4CI3	Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide 分子名称: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... 著者 Fischer, E.S, Boehm, K, Thoma, N.H. 登録日 2013-12-05 公開日 2014-07-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
7Z8T	CAND1-SCF-SKP2 CAND1 engaged SCF rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7ZBW	CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-24 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7Z8R	CAND1-CUL1-RBX1 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7Z8V	CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
6BN7	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC. 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BNB	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6.343 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BN9	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.382 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BOY	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC. 分子名称: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-21 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6DSZ	Crystal structure of DDB1 in complex with DET1- and DDB1-associated protein 1 (DDA1) 分子名称: DET1- and DDB1-associated protein 1, DNA damage-binding protein 1 著者 Shabek, N, Zheng, N. 登録日 2018-06-14 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.093 Å) 主引用文献 Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase. Cell Discov, 4, 2018
4CI1	Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide 分子名称: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... 著者 Fischer, E.S, Boehm, K, Thoma, N.H. 登録日 2013-12-05 公開日 2014-07-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
4CI2	Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide 分子名称: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... 著者 Fischer, E.S, Boehm, K, Thoma, N.H. 登録日 2013-12-05 公開日 2014-07-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
7ZBZ	CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-24 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
3EI2	Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex 分子名称: 5'-D(*DAP*DAP*DAP*DTP*DGP*DAP*DAP*DTP*(3DR)P*DAP*DAP*DGP*DCP*DAP*DGP*DG)-3', 5'-D(*DCP*DCP*DTP*DGP*DCP*DTP*DTP*DTP*DAP*DTP*DTP*DCP*DAP*DTP*DTP*DT)-3', DNA damage-binding protein 1, ... 著者 Scrima, A, Thoma, N.H. 登録日 2008-09-15 公開日 2009-01-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell(Cambridge,Mass.), 135, 2008

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