PDB: 153 件ウェブページステータス検索Chemie searchBIRD

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5V3O	Cereblon in complex with DDB1 and CC-220 分子名称: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Matyskiela, M, Pagarigan, B, Chamberlain, P. 登録日 2017-03-07 公開日 2017-05-03 最終更新日 2018-02-07 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J. Med. Chem., 61, 2018
5UQ3	Crystal structure of human Cdk2-Spy1-P27 ternary complex 分子名称: Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
6BN9	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.382 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BNB	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6.343 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BN7	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC. 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
7B5N	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1. 分子名称: 5-azanylpentan-2-one, Cullin-1, E3 ubiquitin-protein ligase ARIH1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-05 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5R	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27 分子名称: Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-07 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5S	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 分子名称: Cullin-1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase RBX1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-07 公開日 2021-02-10 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 分子名称: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-04 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7B5M	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2 分子名称: Cullin-1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-05 公開日 2021-02-17 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.91 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7Z8B	Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation 分子名称: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ... 著者 Hopf, L.V.M, Schulman, B.A. 登録日 2022-03-17 公開日 2022-08-24 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat.Struct.Mol.Biol., 29, 2022
7ZBZ	CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-24 公開日 2023-04-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7Z8R	CAND1-CUL1-RBX1 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
6PAI	Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 分子名称: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DDB1- and CUL4-associated factor 15, ... 著者 Volkov, O.A, Du, X. 登録日 2019-06-11 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820. Structure, 27, 2019
6R90	Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R91	Cryo-EM structure of NCP_THF2(-3)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R92	Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B 分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R8Z	Cryo-EM structure of NCP_THF2(-1)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
6R8Y	Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... 著者 Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2019-04-02 公開日 2019-06-12 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
7OOP	Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) 分子名称: DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... 著者 Kokic, G, Cramer, P. 登録日 2021-05-28 公開日 2021-10-06 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
7OO3	Pol II-CSB-CSA-DDB1-UVSSA (Structure1) 分子名称: CSB element, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... 著者 Kokic, G, Cramer, P. 登録日 2021-05-26 公開日 2021-10-06 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
7OOB	Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA damage-binding protein 1, ... 著者 Kokic, G, Cramer, P. 登録日 2021-05-27 公開日 2021-10-13 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
7PLO	H. sapiens replisome-CUL2/LRR1 complex 分子名称: Cell division control protein 45 homolog, Claspin, Cullin-2, ... 著者 Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. 登録日 2021-09-01 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021

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