5V3O

Cereblon in complex with DDB1 and CC-220

Summary for 5V3O

Entry DOI	10.2210/pdb5v3o/pdb
Descriptor	DNA damage-binding protein 1, Protein cereblon, (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, ... (4 entities in total)
Functional Keywords	e3, ubiquitin ligase, crl4, dcaf, ligase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q16531 Q96SW2
Total number of polymer chains	2
Total formula weight	174208.94
Authors	Matyskiela, M.,Pagarigan, B.,Chamberlain, P. (deposition date: 2017-03-07, release date: 2017-05-03, Last modification date: 2018-02-07)
Primary citation	Matyskiela, M.E.,Zhang, W.,Man, H.W.,Muller, G.,Khambatta, G.,Baculi, F.,Hickman, M.,LeBrun, L.,Pagarigan, B.,Carmel, G.,Lu, C.C.,Lu, G.,Riley, M.,Satoh, Y.,Schafer, P.,Daniel, T.O.,Carmichael, J.,Cathers, B.E.,Chamberlain, P.P. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J. Med. Chem., 61:535-542, 2018 Cited by PubMed: 28425720 DOI: 10.1021/acs.jmedchem.6b01921 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation