6PAI
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820
Summary for 6PAI
Entry DOI | 10.2210/pdb6pai/pdb |
Descriptor | DNA damage-binding protein 1, DDB1- and CUL4-associated factor 15, RNA-binding protein 39, ... (8 entities in total) |
Functional Keywords | sulfonamide, rbm39, dcaf15, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 208344.63 |
Authors | Volkov, O.A.,Du, X. (deposition date: 2019-06-11, release date: 2019-09-18, Last modification date: 2023-10-11) |
Primary citation | Du, X.,Volkov, O.A.,Czerwinski, R.M.,Tan, H.,Huerta, C.,Morton, E.R.,Rizzi, J.P.,Wehn, P.M.,Xu, R.,Nijhawan, D.,Wallace, E.M. Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820. Structure, 27:1625-1633.e3, 2019 Cited by PubMed: 31693911DOI: 10.1016/j.str.2019.10.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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