6PAI

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0007283	biological_process	spermatogenesis
A	0008283	biological_process	cell population proliferation
A	0010498	biological_process	proteasomal protein catabolic process
A	0010506	biological_process	regulation of autophagy
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031297	biological_process	replication fork processing
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032814	biological_process	regulation of natural killer cell activation
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035861	cellular_component	site of double-strand break
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042127	biological_process	regulation of cell population proliferation
A	0042752	biological_process	regulation of circadian rhythm
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045995	biological_process	regulation of embryonic development
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0060964	biological_process	regulation of miRNA-mediated gene silencing
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0080135	biological_process	regulation of cellular response to stress
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901987	biological_process	regulation of cell cycle phase transition
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1902412	biological_process	regulation of mitotic cytokinesis
A	1904178	biological_process	negative regulation of adipose tissue development
A	2000036	biological_process	regulation of stem cell population maintenance
C	0016567	biological_process	protein ubiquitination
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0005634	cellular_component	nucleus
D	0006397	biological_process	mRNA processing
E	0000209	biological_process	protein polyubiquitination
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0016567	biological_process	protein ubiquitination
E	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032814	biological_process	regulation of natural killer cell activation
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EPE A 1301

Chain	Residue
A	GLY17
A	CYS18
A	GLU65
A	HIS261
A	ASN262
A	ARG263
A	TYR271
A	EPE1302

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EPE A 1302

Chain	Residue
A	HIS261
A	GLU312
A	ARG327
A	EPE1301
A	CYS260

---

site_id	AC3
Number of Residues	13
Details	binding site for residue O6M C 901

Chain	Residue
C	THR230
C	PHE231
C	GLN232
C	PRO233
C	ALA234
C	PHE235
C	VAL477
C	ARG552
C	CYS555
C	VAL556
C	LEU563
D	ASP264
D	MET265

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 902

Chain	Residue
C	CYS193
C	CYS196
C	CYS211
C	HIS214

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	343
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---