PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3IKA	Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002 分子名称: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide 著者 Yun, C.-H, Eck, M.J. 登録日 2009-08-05 公開日 2010-01-12 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature, 462, 2009
3GJR	Caspase-3 Binds Diverse P4 Residues in Peptides 分子名称: Caspase-3 subunit p12, Caspase-3 subunit p17, GLYCEROL, ... 著者 Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T. 登録日 2009-03-09 公開日 2009-03-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009
3IMR	Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol 分子名称: 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2009-08-11 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
3ISU	Crystal structure of the RGC domain of IQGAP3 分子名称: Ras GTPase-activating-like protein IQGAP3 著者 Nedyalkova, L, Tempel, W, Tong, Y, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-08-27 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structure of the RGC domain of IQGAP3 to be published
3IW6	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol 分子名称: Mitogen-activated protein kinase 14, ethyl 4-[(4-benzylpiperazin-1-yl)carbonyl]-1-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylate, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2009-09-02 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
3I7Z	Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2009-07-09 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
3GW5	Crystal structure of human renin complexed with a novel inhibitor 分子名称: (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wu, Z, McKeever, B.M. 登録日 2009-03-31 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg.Med.Chem.Lett., 19, 2009
3GY5	A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 分子名称: 1,2-ETHANEDIOL, BERENIL, CALCIUM ION, ... 著者 Perilo, C.S, Pereira, M.T, Santoro, M.M, Nagem, R.A.P. 登録日 2009-04-03 公開日 2010-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol., 46, 2010
3LPB	Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor 分子名称: N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide, Tyrosine-protein kinase JAK2 著者 Tavares, G.A, Pissot-Soldermann, C, Gerspacher, M, Furet, P, Kroemer, M. 登録日 2010-02-05 公開日 2010-04-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors Bioorg.Med.Chem.Lett., 20, 2010
3H0V	Human AdoMetDC with 5'-Deoxy-5'-(dimethylsulfonio) adenosine 分子名称: 1,4-DIAMINOBUTANE, 5'-deoxy-5'-(dimethyl-lambda~4~-sulfanyl)adenosine, PYRUVIC ACID, ... 著者 Bale, S, Brooks, W.H, Hanes, J.W, Mahesan, A.M, Guida, W.C, Ealick, S.E. 登録日 2009-04-10 公開日 2009-06-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry, 48, 2009
3LD6	Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole 分子名称: 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Lanosterol 14-alpha demethylase, ... 著者 Strushkevich, N, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-01-12 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of human CYP51 inhibition by antifungal azoles. J.Mol.Biol., 397, 2010
3GJS	Caspase-3 Binds Diverse P4 Residues in Peptides 分子名称: Ac-YVAD-Cho inhibitor, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Fang, B, Fu, G, Agniswamy, J, Harrison, R.W, Weber, I.T. 登録日 2009-03-09 公開日 2009-03-24 最終更新日 2011-08-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling. Apoptosis, 14, 2009
3L5X	Crystal structure of the complex between IL-13 and H2L6 FAB 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, H2L6 HEAVY CHAIN, ... 著者 Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. 登録日 2009-12-22 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Human framework adaptation of a mouse anti-human IL-13 antibody. J.Mol.Biol., 398, 2010
3LP7	Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution 分子名称: Arginase-1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE 著者 Di Costanzo, L, Christianson, D.W. 登録日 2010-02-04 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Inhibition of human arginase I by substrate and product analogues. Arch.Biochem.Biophys., 496, 2010
3LQC	X-ray crystal structure of oxidized XRCC1 bound to DNA pol beta Palm thumb domain 分子名称: CARBONATE ION, DNA polymerase beta, DNA repair protein XRCC1, ... 著者 Cuneo, M.J, Krahn, J.M, London, R.E. 登録日 2010-02-09 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.349 Å) 主引用文献 Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase beta binding affinity. Proc.Natl.Acad.Sci.USA, 107, 2010
3L8V	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor 分子名称: 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-N-(2,4-difluorophenyl)pyridine-3-carboxamide, Hepatocyte growth factor receptor 著者 Sack, J. 登録日 2010-01-04 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3H8B	A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9) 分子名称: Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide 著者 Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. 登録日 2009-04-29 公開日 2009-10-20 最終更新日 2014-02-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors J.Med.Chem., 52, 2009
3GY3	A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 分子名称: 1,2-ETHANEDIOL, 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, CALCIUM ION, ... 著者 Perilo, C.S, Pereira, M.T, Santoro, M.M, Nagem, R.A.P. 登録日 2009-04-03 公開日 2010-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol., 46, 2010
3KVF	Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Davies, C.W, Maiti, T.K, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3KVQ	Crystal structure of VEGFR2 extracellular domain D7 分子名称: Vascular endothelial growth factor receptor 2 著者 Yang, Y, Opatowsky, Y, Xie, P, Schlessinger, J. 登録日 2009-11-30 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling Proc.Natl.Acad.Sci.USA, 107, 2010
3KW5	Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Maiti, T.K, Boudreaux, D.A, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3KJY	Crystal structure of reduced HOMO SAPIENS CLIC3 分子名称: Chloride intracellular channel protein 3, SULFATE ION 著者 Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. 登録日 2009-11-04 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of human CLIC3 at 2 A resolution Proteins, 78, 2010
3FM6	Crystal Structure Analysis of Fungal Versatile Peroxidase from Pleurotus eryngii 分子名称: CALCIUM ION, FE (III) ION, GLYCEROL, ... 著者 Piontek, K, Martinez, A.T, Choinowski, T, Plattner, D.A. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Structural and Site-directed Mutagenesis Study of Versatile Peroxidase Oxidizing both Mn(II) and Aromatic Substrates To be Published
3FMU	Crystal Structure Analysis of Fungal Versatile Peroxidase from Pleurotus eryngii 分子名称: CACODYLATE ION, CALCIUM ION, FE (III) ION, ... 著者 Piontek, K, Martinez, A.T, Choinowski, T, Plattner, D.A. 登録日 2008-12-22 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.04 Å) 主引用文献 Structural and Site-directed Mutagenesis Study of Versatile Peroxidase Oxidizing both Mn(II) and Aromatic Substrates To be Published
3FOR	Thermolysin Complexed with BNPA (2-Benzyl-3-Nitro Propanoic Acid Amide) 分子名称: (2R)-2-benzyl-3-nitropropanamide, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Wang, S.-F, Jin, J.-Y, Tian, G.-R. 登録日 2008-12-31 公開日 2010-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Nitro as ZBG in the inhibition of Thermolysin To be Published

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