3IMR

Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol

Summary for 3IMR

Entry DOI	10.2210/pdb3imr/pdb
Related	2QGB 2QGC 2QGD 2QGE 3ESN 3ESO 3IMS 3IMT 3IMU 3IMV 3IMW
Descriptor	Transthyretin, 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol (3 entities in total)
Functional Keywords	hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28400.57
Authors	Connelly, S.,Wilson, I.A. (deposition date: 2009-08-11, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citation	Choi, S.,Reixach, N.,Connelly, S.,Johnson, S.M.,Wilson, I.A.,Kelly, J.W. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132:1359-1370, 2010 Cited by PubMed: 20043671 DOI: 10.1021/ja908562q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation