3LPB
Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor
Summary for 3LPB
Entry DOI | 10.2210/pdb3lpb/pdb |
Related | 3KRR |
Descriptor | Tyrosine-protein kinase JAK2, N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide (3 entities in total) |
Functional Keywords | small molecule inhibitor, atp site kinase inhibitor, novartis product nvp-blu040, atp-binding, chromosomal rearrangement, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
Total number of polymer chains | 2 |
Total formula weight | 70376.01 |
Authors | Tavares, G.A.,Pissot-Soldermann, C.,Gerspacher, M.,Furet, P.,Kroemer, M. (deposition date: 2010-02-05, release date: 2010-04-28, Last modification date: 2023-11-22) |
Primary citation | Pissot-Soldermann, C.,Gerspacher, M.,Furet, P.,Gaul, C.,Holzer, P.,McCarthy, C.,Radimerski, T.,Regnier, C.H.,Baffert, F.,Drueckes, P.,Tavares, G.A.,Vangrevelinghe, E.,Blasco, F.,Ottaviani, G.,Ossola, F.,Scesa, J.,Reetz, J. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors Bioorg.Med.Chem.Lett., 20:2609-2613, 2010 Cited by PubMed: 20231096DOI: 10.1016/j.bmcl.2010.02.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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