3LPB
Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK2 | polymer | 295 | 34722.5 | 2 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | C, D (A, B) | N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | non-polymer | 465.5 | 2 | Chemie (NVB) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A, B: 840 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 838 | - | expression tag |
| Ser 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69445.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 931.0 | |
| All* | Total formula weight | 70376.0 |
