3GY3

A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC

Summary for 3GY3

Entry DOI	10.2210/pdb3gy3/pdb
Related	3GY2 3GY4 3GY5 3GY6 3GY7 3GY8
Descriptor	Cationic trypsin, CALCIUM ION, 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, ... (5 entities in total)
Functional Keywords	bovine beta-trypsin, pentamidine, protein-ligand complex, protein-ligand interaction, calcium, digestion, disulfide bond, hydrolase, metal-binding, protease, secreted, serine protease, zymogen
Biological source	Bos taurus (bovine,cow)
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	1
Total formula weight	24139.26
Authors	Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A.P. (deposition date: 2009-04-03, release date: 2010-03-23, Last modification date: 2011-07-13)
Primary citation	Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol., 46:502-511, 2010 Cited by PubMed: 20356563 DOI: 10.1016/j.ijbiomac.2010.03.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation