3LP7
Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution
Summary for 3LP7
Entry DOI | 10.2210/pdb3lp7/pdb |
Related | 2ZAV 3LP4 5CEV |
Descriptor | Arginase-1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE, ... (4 entities in total) |
Functional Keywords | noha inhibition, manganese cluster, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, polymorphism, urea cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P05089 |
Total number of polymer chains | 2 |
Total formula weight | 70159.91 |
Authors | Di Costanzo, L.,Christianson, D.W. (deposition date: 2010-02-04, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Di Costanzo, L.,Ilies, M.,Thorn, K.J.,Christianson, D.W. Inhibition of human arginase I by substrate and product analogues. Arch.Biochem.Biophys., 496:101-108, 2010 Cited by PubMed: 20153713DOI: 10.1016/j.abb.2010.02.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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