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3H8B

A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9)

Summary for 3H8B
Entry DOI10.2210/pdb3h8b/pdb
Related3H89 3H8C
DescriptorCathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide (3 entities in total)
Functional Keywordscysteine proteases, cathepsin l, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P07711
Total number of polymer chains6
Total formula weight150797.22
Authors
Tulsidas, S.R.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. (deposition date: 2009-04-29, release date: 2009-10-20, Last modification date: 2014-02-05)
Primary citationShenoy, R.T.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J.
A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52:6335-6346, 2009
Cited by
PubMed: 19761244
DOI: 10.1021/jm900596y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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