8AVV
| Cryo-EM structure of DrBphP photosensory module in Pr state | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome,Response regulator | 著者 | Wahlgren, W.Y, Takala, H, Westenhoff, S. | 登録日 | 2022-08-27 | 公開日 | 2022-12-21 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural mechanism of signal transduction in a phytochrome histidine kinase. Nat Commun, 13, 2022
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8AVT
| Racemic protein crystal structure of aureocin A53 from Staphylococcus aureus in the presence of glycerol 3-phosphate | 分子名称: | 1,2-ETHANEDIOL, Bacteriocin aureocin A53, D-Aureocin A53, ... | 著者 | Lander, A.J, Baumann, P, Rizkallah, P, Jin, Y, Luk, L.Y.P. | 登録日 | 2022-08-26 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography. Commun Chem, 6, 2023
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8AVQ
| AO75L in Complex with UDP-Xylose | 分子名称: | 1,2-ETHANEDIOL, AO75L, BICINE, ... | 著者 | Laugeri, M.E, Speciale, I, Gimeno, A, Lin, S, Poveda, A, Lowary, T, Van Etten, J.L, Barbero, J.J, De Castro, C, Tonetti, M, Rojas, A.L. | 登録日 | 2022-08-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | AO75L in Complex with UDP-Xylose To Be Published
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8AVP
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8AVO
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVL
| Superoxide dismutase SodFM2 from Bacteroides fragilis | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, Superoxide dismutase [Fe] | 著者 | Basle, A, Barwinska-Sendra, A, Sendra, K.M, Waldron, K. | 登録日 | 2022-08-26 | 公開日 | 2023-04-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | An ancient metalloenzyme evolves through metal preference modulation. Nat Ecol Evol, 7, 2023
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8AVJ
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8AVI
| Crystal structure of IsdG from Bacillus cereus in complex with heme | 分子名称: | 1,3-PROPANDIOL, 1,4-BUTANEDIOL, Heme-degrading monooxygenase, ... | 著者 | Andersen, H.K, Hammerstad, M, Hersleth, H.-P. | 登録日 | 2022-08-26 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction. Antioxidants, 12, 2023
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8AVH
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8AVF
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (6.45 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVE
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (5.62 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVA
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8AV9
| INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1 | 分子名称: | (3R,6R,7S,8E,11S,12R,22S)-6'-chloro-7-methoxy-11,12-dimethyl-13,13-dioxo-spiro[20-oxa-13-gamma6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene-22,1'-tetralin]-15-one, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Hargreaves, D. | 登録日 | 2022-08-26 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8AV7
| Small molecular stabilizer for ERalpha and 14-3-3 (1074202 - non covalent) | 分子名称: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | 登録日 | 2022-08-26 | 公開日 | 2023-09-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
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8AV2
| Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ... | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AV0
| small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3 | 分子名称: | 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-08-26 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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8AUT
| WelO5* L221A bound to Zn(II), Cl, 2-oxoglutarate, and 12-epi-hapalindole C | 分子名称: | 2-OXOGLUTARIC ACID, 3-[(1~{S},2~{R},3~{S},6~{S})-3-ethenyl-2-isocyano-3-methyl-6-prop-1-en-2-yl-cyclohexyl]-1~{H}-indole, CHLORIDE ION, ... | 著者 | Buller, R, Hueppi, S, Voss, M, Schaub, D. | 登録日 | 2022-08-25 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.685 Å) | 主引用文献 | Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5* Chemcatchem, 2022
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8AUP
| Structure of hARG1 with a novel inhibitor. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, ... | 著者 | Napiorkowska-Gromadzka, A, Nowak, E, Nowotny, M. | 登録日 | 2022-08-25 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol.Cancer Ther., 22, 2023
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8AUO
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8AUM
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8AU4
| Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator | 分子名称: | Ral guanine nucleotide dissociation stimulator-like 2 | 著者 | Tariq, M, Ikeya, T, Togashi, N, Fairall, L, Alejo, C.B, Kamei, S, Alonso, B.R, Campillo, M.A.M, Hudson, A, Ito, Y, Schwabe, J, Dominguez, C, Tanaka, K. | 登録日 | 2022-08-25 | 公開日 | 2023-08-23 | 最終更新日 | 2023-10-25 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator. Life Sci Alliance, 7, 2024
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8AU1
| Jumbo Phage phi-kp24 tail outer sheath | 分子名称: | Putative tail sheath protein | 著者 | Ouyang, R, Briegel, A. | 登録日 | 2022-08-25 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers. Nat Commun, 13, 2022
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8ATZ
| Crystal structure of PPAR gamma (PPARG) in complex with SA112 (compound 2). | 分子名称: | 2-[4-chloranyl-6-[[3-(2-phenylethoxy)phenyl]amino]pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | 著者 | Chaikuad, A, Arifi, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-08-24 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145, 2023
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8ATY
| Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1). | 分子名称: | 2-[4-chloranyl-6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | 著者 | Chaikuad, A, Pollinger, J, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-08-24 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145, 2023
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8ATW
| Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex with 6-mer RNA, pppGpGpApApApU (IC6) | 分子名称: | DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Goovaerts, Q, Shen, J, Patel, S.S, Das, K. | 登録日 | 2022-08-24 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
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