8AV0

small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3

Summary for 8AV0

Entry DOI	10.2210/pdb8av0/pdb
Descriptor	14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	ppi stabilization, 14-3-3, c-raf, disulfide tethering, surfactant protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	28152.37
Authors	Visser, E.J.,Sijbesma, E.,Ottmann, C. (deposition date: 2022-08-26, release date: 2023-04-26, Last modification date: 2024-02-07)
Primary citation	Kenanova, D.N.,Visser, E.J.,Virta, J.M.,Sijbesma, E.,Centorrino, F.,Vickery, H.R.,Zhong, M.,Neitz, R.J.,Brunsveld, L.,Ottmann, C.,Arkin, M.R. A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9:937-946, 2023 Cited by PubMed: 37252362 DOI: 10.1021/acscentsci.2c01449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation