8AV0
small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 9 | 1013.0 | 1 | UniProt (P04049) | Homo sapiens | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D, E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | G (A) | 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide | non-polymer | 488.1 | 1 | Chemie (O6C) | |||
| 6 | H, I (A, P) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
P: 256 - 264 (UniProt: P04049)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 264 | His 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27555.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 596.5 | |
| All* | Total formula weight | 28152.4 |
