8AUP

Structure of hARG1 with a novel inhibitor.

Summary for 8AUP

Entry DOI	10.2210/pdb8aup/pdb
Descriptor	Arginase-1, MANGANESE (II) ION, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	211315.86
Authors	Napiorkowska-Gromadzka, A.,Nowak, E.,Nowotny, M. (deposition date: 2022-08-25, release date: 2023-03-29, Last modification date: 2024-02-07)
Primary citation	Borek, B.,Nowicka, J.,Gzik, A.,Dziegielewski, M.,Jedrzejczak, K.,Brzezinska, J.,Grzybowski, M.,Stanczak, P.,Pomper, P.,Zagozdzon, A.,Rejczak, T.,Matyszewski, K.,Golebiowski, A.,Olczak, J.,Lisiecki, K.,Tyszkiewicz, M.,Kania, M.,Piasecka, S.,Cabaj, A.,Dera, P.,Mulewski, K.,Chrzanowski, J.,Kusmirek, D.,Sobolewska, E.,Magdycz, M.,Mucha, L.,Masnyk, M.,Golab, J.,Nowotny, M.,Nowak, E.,Napiorkowska-Gromadzka, A.,Pikul, S.,Jazwiec, R.,Dzwonek, K.,Dobrzanski, P.,Meyring, M.,Skowronek, K.,Iwanowski, P.,Zaslona, Z.,Blaszczyk, R. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol.Cancer Ther., 22:807-817, 2023 Cited by PubMed: 36939275 DOI: 10.1158/1535-7163.MCT-22-0721 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation