8AV9

INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1

Summary for 8AV9

• Entry DOI: 10.2210/pdb8av9/pdb
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Fab Heavy Chain, Fab Light Chain, ... (5 entities in total)
• Functional Keywords: mcl1, fab, macrocycle, mcl1-fab_55_c6his, immune system, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 68647.95

Authors

Hargreaves, D. (deposition date: 2022-08-26, release date: 2023-05-24)

• Primary citation: Hargreaves, D.,Carbajo, R.J.,Bodnarchuk, M.S.,Embrey, K.,Rawlins, P.B.,Packer, M.,Degorce, S.L.,Hird, A.W.,Johannes, J.W.,Chiarparin, E.,Schade, M.; Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.; Proc.Natl.Acad.Sci.USA, 120:e2221967120-e2221967120, 2023; PubMed: 37186857; DOI: 10.1073/pnas.2221967120

Experimental method

X-RAY DIFFRACTION (1.99 Å)