8AV9
INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1
Summary for 8AV9
Entry DOI | 10.2210/pdb8av9/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Fab Heavy Chain, Fab Light Chain, ... (5 entities in total) |
Functional Keywords | mcl1, fab, macrocycle, mcl1-fab_55_c6his, immune system, apoptosis |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 68647.95 |
Authors | Hargreaves, D. (deposition date: 2022-08-26, release date: 2023-05-24, Last modification date: 2024-05-01) |
Primary citation | Hargreaves, D.,Carbajo, R.J.,Bodnarchuk, M.S.,Embrey, K.,Rawlins, P.B.,Packer, M.,Degorce, S.L.,Hird, A.W.,Johannes, J.W.,Chiarparin, E.,Schade, M. Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1. Proc.Natl.Acad.Sci.USA, 120:e2221967120-e2221967120, 2023 Cited by PubMed: 37186857DOI: 10.1073/pnas.2221967120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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