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8AV9

INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AInduced myeloid leukemia cell differentiation protein Mcl-1polymer16218227.61UniProt (Q07820)
Pfam (PF00452)
In PDB
Homo sapiens (human)Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT
2HFab Heavy Chainpolymer23024488.51Mus musculus (Mouse)
3LFab Light Chainpolymer23625318.71Mus musculus (Mouse)
4A(3R,6R,7S,8E,11S,12R,22S)-6'-chloro-7-methoxy-11,12-dimethyl-13,13-dioxo-spiro[20-oxa-13-gamma6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene-22,1'-tetralin]-15-onenon-polymer613.21Chemie (VF8)
5waterwater18.0334Chemie (HOH)
Sequence modifications
A: 174 - 327 (UniProt: Q07820)
PDBExternal DatabaseDetails
Gly 166-expression tag
Pro 167-expression tag
Leu 168-expression tag
Gly 169-expression tag
Ser 170-expression tag
Glu 171-expression tag
Asp 172-expression tag
Asp 173-expression tag
Ser 193Ala 193conflict
Ser 196Thr 196conflict
Leu 199Met 199conflict
Glu 201Arg 201conflict
Ala 202Ser 202conflict
Ala 205Thr 205conflict
Gly 206Ser 206conflict
Arg 208Lys 208conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight68034.7
Non-Polymers*Number of molecules1
Total formula weight613.2
All*Total formula weight68647.9
*Water molecules are not included.

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PDB entries from 2024-07-17

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