PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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4O16	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 分子名称: 1,2-ETHANEDIOL, 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.783 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
2L3Y	Solution structure of mouse IL-6 分子名称: Interleukin-6 著者 Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. 登録日 2010-09-25 公開日 2011-09-28 最終更新日 2013-01-02 実験手法 SOLUTION NMR 主引用文献 Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention. J.Biol.Chem., 287, 2012
4O19	The crystal structure of a mutant NAMPT (G217V) 分子名称: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
4O13	The crystal structure of NAMPT in complex with GNE-618 分子名称: 1,2-ETHANEDIOL, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Coons, M, Brillantes, B, Wang, W. 登録日 2013-12-15 公開日 2014-10-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
5MUS	Structure of the C-terminal domain of a reptarenavirus L protein 分子名称: CHLORIDE ION, GLYCEROL, L protein 著者 Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. 登録日 2017-01-14 公開日 2017-05-17 最終更新日 2017-05-24 実験手法 X-RAY DIFFRACTION (2.009 Å) 主引用文献 Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
5MV0	Structure of an N-terminal domain of a reptarenavirus L protein 分子名称: L protein, PHOSPHATE ION 著者 Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. 登録日 2017-01-14 公開日 2017-05-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
5MUZ	Structure of a C-terminal domain of a reptarenavirus L protein 分子名称: L protein 著者 Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. 登録日 2017-01-14 公開日 2017-05-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.776 Å) 主引用文献 Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
6Z45	CDK9-Cyclin-T1 complex bound by compound 24 分子名称: (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... 著者 Ferguson, A, Collie, G.W. 登録日 2020-05-22 公開日 2020-12-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
2OBQ	Discovery of the HCV NS3/4A Protease Inhibitor SCH503034. Key Steps in Structure-Based Optimization 分子名称: Hepatitis C virus, ZINC ION 著者 Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers Jr, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R, Arasappan, A, Bennett, F, Bogen, S.F, Chen, K, Jao, E, Liu, Y, Love, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V. 登録日 2006-12-19 公開日 2007-07-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J.Med.Chem., 50, 2007
4R9W	Crystal structure of platelet factor 4 complexed with fondaparinux 分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, Platelet factor 4 著者 Cai, Z, Zhu, Z, Liu, Q, Greene, M.I. 登録日 2014-09-08 公開日 2015-12-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun, 6, 2015
5MUY	Structure of a C-terminal domain of a reptarenavirus L protein with m7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, L protein 著者 Rosenthal, M, Gogrefe, N, Reguera, J, Vogel, D, Rauschenberger, B, Cusack, S, Gunther, S, Reindl, S. 登録日 2017-01-14 公開日 2017-05-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structural insights into reptarenavirus cap-snatching machinery. PLoS Pathog., 13, 2017
4R9Y	Crystal structure of KKOFab in complex with platelet factor 4 分子名称: Platelet factor 4, Platelet factor 4 antibody KKO heavy chain, Platelet factor 4 antibody KKO light chain 著者 Cai, Z, Zhu, Z, Liu, Q, Greene, M.I. 登録日 2014-09-08 公開日 2015-12-16 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.11 Å) 主引用文献 Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun, 6, 2015
2A4O	Dual modes of modification of Hepatitis A virus 3C protease by a serine derived beta-lactone: selective crytstallization and high resolution structure of the His102 adduct 分子名称: ACETYL GROUP, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, PHENYLALANINE AMIDE, ... 著者 Yin, J, Bergmann, E.M, Cherney, M.M, Lall, M.S, Jain, R.P, Vederas, J.C, James, M.N.G. 登録日 2005-06-29 公開日 2005-12-27 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-derived beta-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site J.MOL.BIOL., 354, 2005
1SFV	PORCINE PANCREAS PHOSPHOLIPASE A2, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B, Tessari, M, Boelens, R, Dijkman, R, Kaptein, R, De Haas, G.H, Verheij, H.M. 登録日 1996-02-20 公開日 1996-07-11 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor. J.Biomol.NMR, 5, 1995
1SFW	PORCINE PANCREAS PHOSPHOLIPASE A2, NMR, 18 STRUCTURES 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B, Tessari, M, Boelens, R, Dijkman, R, Kaptein, R, De Haas, G.H, Verheij, H.M. 登録日 1996-02-23 公開日 1996-07-11 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor. J.Biomol.NMR, 5, 1995
1XO1	T5 5'-EXONUCLEASE MUTANT K83A 分子名称: 5'-EXONUCLEASE 著者 Ceska, T.A, Suck, D, Sayers, J.R. 登録日 1998-11-19 公開日 1999-04-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endo-and exonucleolytic cleavage. Proc.Natl.Acad.Sci.USA, 96, 1999
4DG2	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 分子名称: MYRISTIC ACID, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
6P94	Human APE1 C65A AP-endonuclease product complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Whitaker, A.W, Stark, W.J, Freudenthal, B.D. 登録日 2019-06-09 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance. Mutagenesis, 35, 2020
6P93	Human APE1 K98A AP-endonuclease product complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Whitaker, A.W, Stark, W.J, Freudenthal, B.D. 登録日 2019-06-09 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance. Mutagenesis, 35, 2020
4DG0	Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP 分子名称: MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Bastidas, A.C, Steichen, J.M, Taylor, S.S. 登録日 2012-01-24 公開日 2012-06-06 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
8OID	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-09 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
8OI8	Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. 登録日 2023-03-22 公開日 2023-08-16 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.28 Å) 主引用文献 Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
2DY5	Crystal structure of rat heme oxygenase-1 in complex with heme and 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane 分子名称: 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE, CHLORIDE ION, Heme oxygenase 1, ... 著者 Sugishima, M, Takahashi, H, Fukuyama, K. 登録日 2006-09-06 公開日 2007-05-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase Biochemistry, 46, 2007
8P81	Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835 分子名称: Cyclin-K, Cyclin-dependent kinase 12, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine 著者 Anand, K, Schmitz, M, Geyer, M. 登録日 2023-05-31 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. J.Biol.Chem., 300, 2023
8ADW	Lipidic alpha-synuclein fibril - polymorph L1C 分子名称: Alpha-synuclein 著者 Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. 登録日 2022-07-11 公開日 2022-10-12 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022

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