8P81

Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835

Summary for 8P81

Entry DOI	10.2210/pdb8p81/pdb
Descriptor	Cyclin-dependent kinase 12, Cyclin-K, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine, ... (4 entities in total)
Functional Keywords	cyclin-dependent kinase, inhibitor, sr-4835, cdk12, cyclin k, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	72693.52
Authors	Anand, K.,Schmitz, M.,Geyer, M. (deposition date: 2023-05-31, release date: 2023-11-22, Last modification date: 2023-12-27)
Primary citation	Schmitz, M.,Kaltheuner, I.H.,Anand, K.,Duster, R.,Moecking, J.,Monastyrskyi, A.,Duckett, D.R.,Roush, W.R.,Geyer, M. The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. J.Biol.Chem., 300:105501-105501, 2023 Cited by PubMed: 38016516 DOI: 10.1016/j.jbc.2023.105501 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation