8P81
Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 12 | polymer | 351 | 40765.0 | 1 | UniProt (Q9NYV4) Pfam (PF00069) | Homo sapiens (human) | Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12 |
| 2 | B (B) | Cyclin-K | polymer | 268 | 31429.2 | 1 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | |
| 3 | C (A) | ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine | non-polymer | 499.4 | 1 | Chemie (RMF) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 714 - 1063 (UniProt: Q9NYV4)
B: 1 - 267 (UniProt: O75909)
| PDB | External Database | Details |
|---|---|---|
| Gly 713 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72194.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 499.4 | |
| All* | Total formula weight | 72693.5 |
