Crystal structure of KKOFab in complex with platelet factor 4

Summary for 4R9Y

Related4R97 4R9W
DescriptorPlatelet factor 4, Platelet factor 4 antibody KKO light chain, Platelet factor 4 antibody KKO heavy chain (3 entities in total)
Functional Keywordskko, pf4, hit, immunoglobulin, cxc chemokine, antibody, antigen, blood, immune system-cytokine complex, immune system/cytokine
Biological sourceHomo sapiens (human)
Cellular locationSecreted  P02776
Total number of polymer chains8
Total molecular weight125212.63
Cai, Z.,Zhu, Z.,Liu, Q.,Greene, M.I. (deposition date: 2014-09-08, release date: 2015-12-16, Last modification date: 2017-11-22)
Primary citation
Cai, Z.,Yarovoi, S.V.,Zhu, Z.,Rauova, L.,Hayes, V.,Lebedeva, T.,Liu, Q.,Poncz, M.,Arepally, G.,Cines, D.B.,Greene, M.I.
Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6:8277-8277, 2015
PubMed: 26391892 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms9277
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.38311 2.9% 6.0% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21