PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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6TIY	DROSOPHILA GMPCPP-TUBULIN 分子名称: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Gigant, B. 登録日 2019-11-22 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.293 Å) 主引用文献 GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. J.Cell Biol., 220, 2021
6TOU	Rabies virus glycoprotein PH domain in complex with the scFv fragment of broadly neutralizing human antibody RVC20 分子名称: CALCIUM ION, CHLORIDE ION, Glycoprotein,Glycoprotein, ... 著者 Hellert, J, Rey, F.A. 登録日 2019-12-12 公開日 2020-02-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.587 Å) 主引用文献 Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein. Nat Commun, 11, 2020
4JBK	Molecular basis for abrogation of activation of pro-inflammatory cytokines 分子名称: DNA (5'-D(P*GP*GP*AP*AP*TP*TP*AP*TP*AP*AP*TP*TP*CP*C)-3'), Interferon-activable protein 202 著者 Ru, H, Ni, X, Crowley, C, Zhao, L, Ding, W, Hung, L.-W, Shaw, N, Cheng, G, Liu, Z.-J. 登録日 2013-02-19 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.963 Å) 主引用文献 Structural basis for termination of AIM2-mediated signaling by p202 Cell Res., 23, 2013
4NPP	The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms 分子名称: NICKEL (II) ION, Proton-gated ion channel 著者 Sauguet, L, Shahsavar, A, Poitevin, F, Huon, C, Menny, A, Nemecz, A, Haouz, A, Changeux, J.P, Corringer, P.J, Delarue, M. 登録日 2013-11-22 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc.Natl.Acad.Sci.USA, 111, 2014
4MCS	A high resolution structure of human glutamate carboxypeptidase II (GCPII) His475Tyr variant in complex with glutamic acid 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASPARTIC ACID, ... 著者 Ptacek, J, Barinka, C, Sacha, P, Navratil, M. 登録日 2013-08-21 公開日 2014-06-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
4MCP	A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyl-gamma-L-glutamic acid (pteroyldi-gamma-L-glutamic acid) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Navratil, M, Barinka, C, Lubkowski, J. 登録日 2013-08-21 公開日 2014-06-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
6S8C	Post-fusion conformation of the envelope protein of tick-borne encephalitis virus with longer stem 分子名称: Genome polyprotein,Genome polyprotein 著者 Vaney, M.C, Rouvinski, A, Rey, F.A. 登録日 2019-07-09 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin. Embo Rep., 21, 2020
4NGQ	Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Tykvart, J, Pachl, P. 登録日 2013-11-02 公開日 2014-06-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22, 2014
4RHP	Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043 分子名称: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Ubiquinone biosynthesis protein COQ9, mitochondrial 著者 Forouhar, F, Lew, S, Seetharaman, J, Wang, H, Lee, D, Kogan, S, Maglaqui, M, Xiao, R, Everett, J.K, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP) 登録日 2014-10-02 公開日 2014-10-22 最終更新日 2019-08-14 実験手法 X-RAY DIFFRACTION (2.393 Å) 主引用文献 Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc.Natl.Acad.Sci.USA, 111, 2014
4OC5	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CHIBzL, a urea-based inhibitor N~2~-{[(S)-carboxy(4-hydroxyphenyl)methyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4GRS	Crystal structure of a chimeric DAH7PS 分子名称: Phospho-2-dehydro-3-deoxyheptonate aldolase, 2-dehydro-3-deoxyphosphoheptonate aldolase, TYROSINE 著者 Cross, P.J, Allison, T.M, Dobson, R.C.J, Jameson, G.B, Parker, E.J. 登録日 2012-08-26 公開日 2013-02-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain Proc.Natl.Acad.Sci.USA, 110, 2013
6TZW	Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility 分子名称: CALCIUM ION, Protein bicaudal D 著者 Cui, H, Solmaz, S.R. 登録日 2019-08-13 公開日 2020-05-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility. Traffic, 21, 2020
4GOS	Crystal structure of human B7-H4 IgV-like domain 分子名称: V-set domain-containing T-cell activation inhibitor 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Vigdorovich, V, Ramagopal, U, Bhosle, R, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) 登録日 2012-08-20 公開日 2012-09-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep, 9, 2014
4JYW	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barinka, C. 登録日 2013-04-01 公開日 2014-04-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer To be Published
6TY5	Crystal structure of human TLR8 in complex with Compound 11 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl)furo[3,2-c]pyridin-4-one, Toll-like receptor 8, ... 著者 Faller, M, Zink, F. 登録日 2020-01-15 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.793 Å) 主引用文献 Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay. J.Med.Chem., 63, 2020
4U0R	Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody 9AD4 分子名称: Monoclonal antibody 9AD4 heavy chain, Monoclonal antibody 9AD4 light chain, Reticulocyte binding protein 5 著者 Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. 登録日 2014-07-14 公開日 2014-08-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature, 515, 2014
6SIE	Crystal structure of the C-lobe of drosophila Arc 2 分子名称: Activity-regulated cytoskeleton associated protein 2, SULFATE ION 著者 Hallin, E.I, Kursula, P. 登録日 2019-08-09 公開日 2019-08-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Plos One, 16, 2021
4TUW	drosophila stem-loop binding protein complexed with histone mRNA stem-loop, phospho mimic of TPNK and C-terminal region 分子名称: CALCIUM ION, HISTONE MRNA 3' STEM LOOP, Histone RNA hairpin-binding protein 著者 Zhang, J. 登録日 2014-06-25 公開日 2014-07-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.902 Å) 主引用文献 Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014
4OC0	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CCIBzL, a urea-based inhibitor N~2~-[(1-carboxycyclopropyl)carbamoyl]-N~6~-(4-iodobenzoyl)-L-lysine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4JZ0	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Barinka, C. 登録日 2013-04-02 公開日 2014-04-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer To be Published
4JZN	Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1 分子名称: Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, Envelope glycoprotein E2, ... 著者 Krey, T, Rey, F.A. 登録日 2013-04-03 公開日 2013-06-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. Plos Pathog., 9, 2013
4JZO	Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27 分子名称: Anti-HCV E2 Fab HC84-27 heavy chain, Anti-HCV E2 Fab HC84-27 light chain, Envelope glycoprotein E2 著者 Krey, T, Rey, F.A. 登録日 2013-04-03 公開日 2013-06-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. Plos Pathog., 9, 2013
6RRN	GOLGI ALPHA-MANNOSIDASE II in complex with pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide 分子名称: (2~{S},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-~{N}-pentyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRY	GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-1,2,3,6-tetrahydro-3-pyridinol 分子名称: (2~{S},3~{R})-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
4TV0	Drosophila stem-loop binding protein complexed with histone mRNA stem-loop, Selenomethionine derivative 分子名称: CALCIUM ION, Histone RNA hairpin-binding protein, RNA (26-MER) 著者 Zhang, J. 登録日 2014-06-25 公開日 2014-09-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014

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