6TY5

Crystal structure of human TLR8 in complex with Compound 11

Summary for 6TY5

• Entry DOI: 10.2210/pdb6ty5/pdb
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: rna recognition leucine rich repeats glycosylation structure based drug design immune system innate immunity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 192811.25

Authors

Faller, M.,Zink, F. (deposition date: 2020-01-15, release date: 2020-08-12, Last modification date: 2024-01-24)

• Primary citation: Knoepfel, T.,Nimsgern, P.,Jacquier, S.,Bourrel, M.,Vangrevelinghe, E.,Glatthar, R.,Behnke, D.,Alper, P.B.,Michellys, P.Y.,Deane, J.,Junt, T.,Zipfel, G.,Limonta, S.,Hawtin, S.,Andre, C.,Boulay, T.,Loetscher, P.,Faller, M.,Blank, J.,Feifel, R.,Betschart, C.; Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.; J.Med.Chem., 63:8276-8295, 2020; PubMed: 32786235; DOI: 10.1021/acs.jmedchem.0c00130

Experimental method

X-RAY DIFFRACTION (2.793 Å)