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4JYW

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057

Summary for 4JYW
Entry DOI10.2210/pdb4jyw/pdb
Related4JZ0
DescriptorGlutamate carboxypeptidase 2, N-{6-[(4-fluorobenzoyl)amino]hexanoyl}-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywordshydrolase, metallopeptidase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
Total number of polymer chains1
Total formula weight84131.11
Authors
Barinka, C. (deposition date: 2013-04-01, release date: 2014-04-02, Last modification date: 2020-07-29)
Primary citationGanguly, T.,Dannoon, S.,Geruntho, J.G.,Hopkins, M.R.,Murphy, S.,Cahaya, H.,Blecha, J.E.,Jivan, S.,Barinka, C.,Jones, E.F.,VanBrocklin, H.F.,Berkman, C.E.
A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer
To be Published,
Experimental method
X-RAY DIFFRACTION (1.73 Å)
Structure validation

217705

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