4JZ0

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055

Summary for 4JZ0

• Entry DOI: 10.2210/pdb4jz0/pdb
• Related: 4JYW
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hydrolase, metallopeptidase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• Total number of polymer chains: 1
• Total formula weight: 83316.29

Authors

Barinka, C. (deposition date: 2013-04-02, release date: 2014-04-02, Last modification date: 2020-07-29)

• Primary citation: Ganguly, T.,Dannoon, S.,Geruntho, J.G.,Hopkins, M.R.,Murphy, S.,Cahaya, H.,Blecha, J.E.,Jivan, S.,Barinka, C.,Jones, E.F.,VanBrocklin, H.F.,Berkman, C.E.; A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer; To be Published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)