4JZ0

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate carboxypeptidase 2	polymer	709	79859.0	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB	Homo sapiens (human)	Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase
2	B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
3	E	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
8	A	N-(4-fluorobenzoyl)-L-gamma-glutamyl-O-[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]-L-serine	non-polymer		565.4	1	Chemie (T01)
9		water	water		18.0	433	Chemie (HOH)

Sequence modifications

A: 44 - 750 (UniProt: Q04609)

PDB	External Database	Details
Arg 42	-	expression tag
Ser 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	79859.0
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1435.4
All*	Total formula weight	83316.3

*Water molecules are not included.