6TGG
 
 | | scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar | | 分子名称: | 1,2-ETHANEDIOL, Mucin-1, ScFv_SM3, ... | | 著者 | Bermejo, I.A, Navo, C.D, Castro-Lopez, J, Samchez-Fernandez, E.M, Guerreiro, A, Avenoza, A, Busto, J.H, Garcia-Martin, F, Nishimura, S.I, Garcia-Fernandez, J.M, Ortiz-Mellet, C, Bernardes, G.J.L, Hurtado-Guerrero, R, Peregrina, J.M, Corzana, F. | | 登録日 | 2019-11-15 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp 2 -iminosugar fragment.
Chem Sci, 11, 2020
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5VKK
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5VKE
 | | Open conformation of KcsA deep-inactivated | | 分子名称: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | | 著者 | Cuello, L.G, Perozo, E, Cortes, D.M. | | 登録日 | 2017-04-21 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
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5VL3
 | | CD22 d1-d3 in complex with therapeutic Fab Epratuzumab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell receptor CD22, Epratuzumab Fab Heavy Chain, ... | | 著者 | Sicard, T, Ereno-Orbea, J, Julien, J.P. | | 登録日 | 2017-04-24 | | 公開日 | 2017-10-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
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8GHK
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6Z2M
 | | H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 antibody, Spike glycoprotein, ... | | 著者 | Naismith, J.H, Ren, J, Zhou, D, Zhao, Y, Stuart, D.I. | | 登録日 | 2020-05-17 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structural characterisation of a nanobody derived from a naive library that neutralises SARS-CoV-2
To Be Published
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7YD3
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7CVT
 | | Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | | 著者 | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | | 登録日 | 2020-08-27 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.
J.Mol.Biol., 433, 2021
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7CVS
 | | Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | | 著者 | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | | 登録日 | 2020-08-27 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.
J.Mol.Biol., 433, 2021
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2Y7S
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8DPG
 | | Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to psilocin | | 分子名称: | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | | 著者 | Gumpper, R.H, Fay, J.F, Roth, B.L. | | 登録日 | 2022-07-15 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
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8DPI
 | | Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin | | 分子名称: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | | 著者 | Gumpper, R.H, Fay, J.F, Roth, B.L. | | 登録日 | 2022-07-15 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
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8DPF
 | | Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin | | 分子名称: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | | 著者 | Gumpper, R.H, Fay, J.F, Roth, B.L. | | 登録日 | 2022-07-15 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
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8DPH
 | | Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin | | 分子名称: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | | 著者 | Gumpper, R.H, Fay, J.F, Roth, B.L. | | 登録日 | 2022-07-15 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
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8F38
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6CO3
 | | aducanumab abeta complex | | 分子名称: | ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ... | | 著者 | Arndt, J.W. | | 登録日 | 2018-03-10 | | 公開日 | 2018-05-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
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6CNR
 | | aducanumab apo Fab | | 分子名称: | Aducanumab heavy chain, Aducanumab light chain, SULFATE ION | | 著者 | Arndt, J.W. | | 登録日 | 2018-03-08 | | 公開日 | 2018-05-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
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3SGE
 | | Crystal structure of mAb 17.2 in complex with R13 peptide | | 分子名称: | CALCIUM ION, Heavy Chain, Light Chain, ... | | 著者 | Pizarro, J.C, Boulot, G, Hontebeyrie, M, Bentley, G.A. | | 登録日 | 2011-06-14 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2 Beta protein: implications in cross-reactivity
Plos Negl Trop Dis, 5, 2011
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5FXC
 | | Crystal structure of glycopeptide 22 in complex with scFv-SM3 | | 分子名称: | 1,2-ETHANEDIOL, GLYCOPEPTIDE, SCFV-SM3 | | 著者 | Rojas-Ocariz, V, Companon, I, Aydillo, C, Castro-Lopez, J, Jimenez-Barbero, J, Hurtado-Guerrero, R, Avenoza, A, Zurbano, M.M, Corzana, F, Busto, J.H, Peregrina, J.M. | | 登録日 | 2016-02-29 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Design of Alpha-S-Glycopeptides Derived from Muc1 with a Flexible and Solvent Exposed Sugar Moiety
J.Org.Chem., 81, 2016
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7U0Y
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5O2U
 | | Llama VHH in complex with p24 | | 分子名称: | Capsid protein p24, VHH 59H10 | | 著者 | Caillat, C, Verrips, T, Weissenhorn, W. | | 登録日 | 2017-05-22 | | 公開日 | 2017-06-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights.
ACS Infect Dis, 3, 2017
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1YC7
 | | cAbAn33 VHH fragment against VSG | | 分子名称: | SULFATE ION, anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | 著者 | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | 登録日 | 2004-12-22 | | 公開日 | 2005-06-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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1YC8
 | | cAbAn33- Y37V/E44G/R45L triple mutant | | 分子名称: | anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | 著者 | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | 登録日 | 2004-12-22 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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1YZZ
 | | Humanized caban33 at room temperature | | 分子名称: | anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | 著者 | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Decanniere, K, Muyldermans, S, Loris, R. | | 登録日 | 2005-03-01 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH.
J.Mol.Biol., 350, 2005
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1ZA3
 | | The crystal structure of the YSd1 Fab bound to DR5 | | 分子名称: | Fab-YSd1 heavy chain, Fab-YSd1 light chain, Tumor necrosis factor receptor superfamily member 10B | | 著者 | Fellouse, F.A, Li, B, Compaan, D.M, Peden, A.A, Hymowitz, S.G, Sidhu, S.S. | | 登録日 | 2005-04-05 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Molecular recognition by a binary code.
J.Mol.Biol., 348, 2005
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