3FJH
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6MG1
| C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2 Crystal Form | 分子名称: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta, ... | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2018-09-12 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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5JCP
| RhoGAP domain of ARAP3 in complex with RhoA in the transition state | 分子名称: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3,Linker,Transforming protein RhoA, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Bao, H, Li, F, Wang, C, Wang, N, Jiang, Y, Tang, Y, Wu, J, Shi, Y. | 登録日 | 2016-04-15 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem., 291, 2016
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6MG3
| V285A Mutant of the C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence | 分子名称: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2018-09-12 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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6MG2
| C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2221 Crystal Form | 分子名称: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2018-09-12 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.928 Å) | 主引用文献 | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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1PME
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5IRC
| p190A GAP domain complex with RhoA | 分子名称: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Derewenda, U, Derewenda, Z. | 登録日 | 2016-03-12 | 公開日 | 2016-08-17 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. J.Biol.Chem., 291, 2016
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6LQG
| Human gamma-secretase in complex with small molecule Avagacestat | 分子名称: | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | 登録日 | 2020-01-13 | 公開日 | 2021-01-27 | 最終更新日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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6LR4
| Molecular basis for inhibition of human gamma-secretase by small molecule | 分子名称: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | 登録日 | 2020-01-15 | 公開日 | 2021-01-27 | 最終更新日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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3B4V
| X-Ray structure of Activin in complex with FSTL3 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... | 著者 | Thompson, T.B. | 登録日 | 2007-10-24 | 公開日 | 2008-09-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
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4A0C
| Structure of the CAND1-CUL4B-RBX1 complex | 分子名称: | CULLIN-4B, CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1, E3 UBIQUITIN-PROTEIN LIGASE RBX1, ... | 著者 | Scrima, A, Fischer, E.S, Faty, M, Gut, H, Thoma, N.H. | 登録日 | 2011-09-08 | 公開日 | 2011-11-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
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3C99
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1O80
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1O7Z
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5FUC
| Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ... | 著者 | Adams, R, Griffin, R, Doyle, C, Ettorre, A. | 登録日 | 2016-01-25 | 公開日 | 2017-01-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep, 7, 2017
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6WG3
| Cryo-EM structure of human Cohesin-NIPBL-DNA complex | 分子名称: | Cohesin subunit SA-1, DNA (51-MER), Double-strand-break repair protein rad21 homolog, ... | 著者 | Shi, Z.B, Gao, H, Bai, X.C, Yu, H. | 登録日 | 2020-04-04 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | 主引用文献 | Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Science, 368, 2020
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3DQV
| Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation | 分子名称: | Cullin-5, NEDD8, Rbx1, ... | 著者 | Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A. | 登録日 | 2008-07-09 | 公開日 | 2008-09-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell(Cambridge,Mass.), 134, 2008
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1O7Y
| Crystal structure of IP-10 M-form | 分子名称: | SMALL INDUCIBLE CYTOKINE B10, SULFATE ION | 著者 | Swaminathan, G.J, Holloway, D.E, Papageorgiou, A.C, Acharya, K.R. | 登録日 | 2002-11-20 | 公開日 | 2003-05-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structures of Oligomeric Forms of the Ip-10/Cxcl10 Chemokine Structure, 11, 2003
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6CU7
| Alpha Synuclein fibril formed by full length protein - Rod Polymorph | 分子名称: | Alpha-synuclein | 著者 | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | 登録日 | 2018-03-23 | 公開日 | 2018-09-12 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun, 9, 2018
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3EMH
| Structural basis of WDR5-MLL interaction | 分子名称: | Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5 | 著者 | Song, J.J, Kingston, R.E. | 登録日 | 2008-09-24 | 公開日 | 2008-10-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. J.Biol.Chem., 283, 2008
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6NUC
| Structure of Calcineurin in complex with NHE1 peptide | 分子名称: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wang, X, Page, R, Peti, W. | 登録日 | 2019-01-31 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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3FJJ
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1PE0
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1XBR
| T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA | 分子名称: | DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*G P*TP*GP*AP*AP*AP* TP*T)-3'), PROTEIN (T PROTEIN) | 著者 | Muller, C.W. | 登録日 | 1997-07-16 | 公開日 | 1998-01-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor. Nature, 389, 1997
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1FU9
| SOLUTION STRUCTURE OF THE NINTH ZINC-FINGER DOMAIN OF THE U-SHAPED TRANSCRIPTION FACTOR | 分子名称: | U-SHAPED TRANSCRIPTIONAL COFACTOR, ZINC ION | 著者 | Liew, C.K, Kowalski, K, Fox, A.H, Newton, A, Sharpe, B.K, Crossley, M, Mackay, J.P. | 登録日 | 2000-09-14 | 公開日 | 2000-10-04 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure Fold.Des., 8, 2000
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