PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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8GSV	Crystal structure of human BAK in complex with the Pxt1 BH3 domain 分子名称: Bcl-2 homologous antagonist/killer, Peroxisomal testis-specific protein 1 著者 Lim, D, Ku, B. 登録日 2022-09-07 公開日 2023-05-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1. Plos Biol., 21, 2023
6LJA	Crystal Structure of exoHep from Bacteroides intestinalis DSM 17393 complexed with disaccharide product 分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein 著者 Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. 登録日 2019-12-13 公開日 2020-12-23 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun, 12, 2021
7DNN	Crystal structure of the AgCarB2-C2 complex with homoorientin 分子名称: 2-[3,4-bis(oxidanyl)phenyl]-6-[(2S,3R,4R,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]-5,7-bis(oxidanyl)chromen-4-one, AP_endonuc_2 domain-containing protein, AgCarC2, ... 著者 Senda, M, Kumano, T, Watanabe, S, Kobayashi, M, Senda, T. 登録日 2020-12-10 公開日 2021-10-20 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for the metabolism of xenobiotic C-glycosides by intestinal bacteria Nat Commun, 2021
7DNM	Crystal structure of the AgCarB2-C2 complex 分子名称: AP_endonuc_2 domain-containing protein, AgCarC2, IODIDE ION, ... 著者 Senda, M, Kumano, T, Watanabe, S, Kobayashi, M, Senda, T. 登録日 2020-12-10 公開日 2021-10-20 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the metabolism of xenobiotic C-glycosides by intestinal bacteria Nat Commun, 2021
8E3Z	Cryo-EM structure of the VPAC1R-VIP-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Piper, S.J, Danev, R, Sexton, P, Wootten, D. 登録日 2022-08-17 公開日 2022-11-23 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13, 2022
5I4V	Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists 分子名称: Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol 著者 Chen, G, McKeever, B.M. 登録日 2016-02-12 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
7OQD	A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT1636-S1_20) 分子名称: 3-O-sulfo-beta-D-galactopyranose, Arylsulfatase, CALCIUM ION 著者 Sofia de Jesus Vaz Luis, A, Basle, A, Martens, E.C, Cartmell, A. 登録日 2021-06-03 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A single sulfatase is required to access colonic mucin by a gut bacterium. Nature, 598, 2021
5O38	Human Brd2(BD2) mutant in free form 分子名称: (2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol, 3-[(2~{R})-2-oxidanylpropoxy]-2-[[(2~{R})-2-oxidanylpropoxy]methyl]-2-[[(2~{S})-2-oxidanylpropoxy]methyl]propan-1-ol, Bromodomain-containing protein 2, ... 著者 Chan, K.-H, Runcie, A.C, Ciulli, A. 登録日 2017-05-23 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9, 2018
5O3C	Human Brd2(BD2) mutant in complex with 9-Me 分子名称: (2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol, Bromodomain-containing protein 2, CHLORIDE ION, ... 著者 Runcie, A.C, Chan, K.-H, Ciulli, A. 登録日 2017-05-23 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9, 2018
6VN7	Cryo-EM structure of an activated VIP1 receptor-G protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. 登録日 2020-01-29 公開日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
6YLZ	X-ray structure of the K72I,Y129F,R133L, H199A quadruple mutant of PNP-oxidase from E. coli 分子名称: FLAVIN MONONUCLEOTIDE, PHOSPHATE ION, Pyridoxine/pyridoxamine 5'-phosphate oxidase, ... 著者 Battista, T, Sularea, M, Barile, A, Fiorillo, A, Tramonti, A, Ilari, A. 登録日 2020-04-07 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.558 Å) 主引用文献 Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase. J.Biol.Chem., 296, 2021
6YMH	X-ray structure of the K72I, Y129F, R133L, H199A quadruple mutant of PNP-oxidase from E. coli in complex with PLP 分子名称: FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, Pyridoxine/pyridoxamine 5'-phosphate oxidase, ... 著者 Battista, T, Sularea, M, Barile, A, Fiorillo, A, Tramonti, A, Ilari, A. 登録日 2020-04-08 公開日 2021-04-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.417 Å) 主引用文献 Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase. J.Biol.Chem., 296, 2021
8E3Y	Cryo-EM structure of the VPAC1R-PACAP27-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Piper, S.J, Danev, R, Sexton, P, Wootten, D. 登録日 2022-08-17 公開日 2022-11-23 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13, 2022
3MSS	Abl kinase in complex with imatinib and fragment (FRAG2) in the myristate site 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, O-benzyl-N-methyl-L-tyrosinamide, Tyrosine-protein kinase ABL1 著者 Cowan-Jacob, S.W, Rummel, G, Fendrich, G. 登録日 2010-04-29 公開日 2010-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay. J.Am.Chem.Soc., 132, 2010
8G4S	40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs. 分子名称: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S25, ... 著者 Eiler, D.R, Wimberly, B.T, Bilodeau, D.Y, Rissland, O.S, Kieft, J.S. 登録日 2023-02-10 公開日 2024-01-31 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure, 32, 2024
8OV6	Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB 分子名称: Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DDB1deltaBPB, ... 著者 Cowan, A.D, Sundaramoorthy, R, Nakasone, M.A, Ciulli, A. 登録日 2023-04-25 公開日 2023-05-17 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.77 Å) 主引用文献 Targeted protein degradation via intramolecular bivalent glues. Nature, 627, 2024
4UY9	Structure of MLK1 kinase domain with leucine zipper 1 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 著者 Read, J.A, Brassington, C, Pollard, H.K, Phillips, C, Green, I, Overmann, R, Collier, M. 登録日 2014-08-29 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Recurrent Mlk4 Loss-of-Function Mutations Suppress Jnk Signaling to Promote Colon Tumorigenesis. Cancer Res., 76, 2016
4UYA	Structure of MLK4 kinase domain with ATPgammaS 分子名称: MAGNESIUM ION, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Read, J.A, Brassington, C, Pollard, H.K, Phillips, C, Green, I, Overmann, R, Collier, M. 登録日 2014-08-29 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Recurrent Mlk4 Loss-of-Function Mutations Suppress Jnk Signaling to Promote Colon Tumorigenesis. Cancer Res., 76, 2016
4EN4	Crystal Structure of the Ternary Human PL Kinase-Ginkgotoxin-MgATP Complex 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Safo, M.K, Musayev, F.N, Gandhi, A.K. 登録日 2012-04-12 公開日 2012-05-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition. Plos One, 7, 2012
7ALL	A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT4683-S1_4) 分子名称: Arylsulfatase, CALCIUM ION, IODIDE ION, ... 著者 Sofia de Jesus Vaz Luis, A, Martens, E.C, Basle, A, Cartmell, A. 登録日 2020-10-06 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 A single sulfatase is required to access colonic mucin by a gut bacterium. Nature, 598, 2021
7AN1	A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT1636-S1_20) 分子名称: Arylsulfatase, CALCIUM ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Sofia de Jesus Vaz Luis, A, Basle, A, Martens, E.C, Cartmell, A. 登録日 2020-10-10 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A single sulfatase is required to access colonic mucin by a gut bacterium. Nature, 598, 2021
7ANB	A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT1622-S1_20) 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, N-acetylgalactosamine-6-sulfatase, ... 著者 Sofia de Jesus Vaz Luis, A, Basle, A, Martens, E.C, Cartmell, A. 登録日 2020-10-11 公開日 2021-10-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A single sulfatase is required to access colonic mucin by a gut bacterium. Nature, 598, 2021
7ANA	A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT1622-S1_20) 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... 著者 Sofia de Jesus Vaz Luis, A, Basle, A, Martens, E.C, Cartmell, A. 登録日 2020-10-11 公開日 2021-11-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A single sulfatase is required to access colonic mucin by a gut bacterium. Nature, 598, 2021
7EXZ	DgpB-DgpC complex apo 2.5 angstrom 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AP_endonuc_2 domain-containing protein, DgpB, ... 著者 Mori, T, Senda, M, Senda, T, Abe, I. 登録日 2021-05-29 公開日 2021-11-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat Commun, 12, 2021
6RP9	Crystal structure of the T-cell receptor NYE_S3 bound to HLA A2*01-SLLMWITQV 分子名称: Beta-2-microglobulin, Cancer/testis antigen 1, HLA class I histocompatibility antigen, ... 著者 Coles, C.H, Mulvaney, R, Malla, S, Lloyd, A, Smith, K, Chester, F, Knox, A, Stacey, A.R, Dukes, J, Baston, E, Griffin, S, Vuidepot, A, Jakobsen, B.K, Harper, S. 登録日 2019-05-14 公開日 2020-01-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex. J Immunol., 204, 2020

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