7L9A

Crystal structure of BRDT bromodomain 2 in complex with CDD-1102

Summary for 7L9A

Entry DOI	10.2210/pdb7l9a/pdb
Descriptor	Bromodomain testis-specific protein, N~1~-(5-{[3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carbonyl]amino}-2-methylphenyl)-N~4~-methylbenzene-1,4-dicarboxamide, BETA-MERCAPTOETHANOL, ... (4 entities in total)
Functional Keywords	transcription/inhibitor, transcription-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	32801.59
Authors	Sharma, R.,Kaur, G.,Yu, Z.,Ku, A.F.,Anglin, J.L.,Ucisik, M.N.,Faver, J.C.,Sankaran, B.,Kim, C.,Matzuk, M.M. (deposition date: 2021-01-03, release date: 2021-06-30, Last modification date: 2023-10-18)
Primary citation	Yu, Z.,Ku, A.F.,Anglin, J.L.,Sharma, R.,Ucisik, M.N.,Faver, J.C.,Li, F.,Nyshadham, P.,Simmons, N.,Sharma, K.L.,Nagarajan, S.,Riehle, K.,Kaur, G.,Sankaran, B.,Storl-Desmond, M.,Palmer, S.S.,Young, D.W.,Kim, C.,Matzuk, M.M. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33637650 DOI: 10.1073/pnas.2021102118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation