7L9A

Crystal structure of BRDT bromodomain 2 in complex with CDD-1102

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ALS BEAMLINE 8.2.1
Synchrotron site	ALS
Beamline	8.2.1
Temperature [K]	100
Detector technology	CCD
Collection date	2019-07-20
Detector	ADSC QUANTUM 315r
Wavelength(s)	1
Spacegroup name	P 32 2 1
Unit cell lengths	56.470, 56.470, 191.901
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	48.900 - 2.270
R-factor	0.2365
Rwork	0.235
R-free	0.26540
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	4uyg
RMSD bond length	0.005
RMSD bond angle	0.827
Data reduction software	iMOSFLM
Data scaling software	SCALA
Phasing software	PHASER
Refinement software	PHENIX (1.17.1_3660)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	48.900	2.350
High resolution limit [Å]	2.270	2.270
Number of reflections	17166	1680
<I/σ(I)>	4.4
Completeness [%]	99.6
Redundancy	2
CC(1/2)	0.980	0.410

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION	7	298	0.8 M succinic acid