5O39

Human Brd2(BD2) mutant in complex with ME

Summary for 5O39

Entry DOI	10.2210/pdb5o39/pdb
Descriptor	Bromodomain-containing protein 2, methyl (2R)-2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]propanoate, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	the bromodomain and extra-terminal domain (bet) family chromatin binding protein, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P25440
Total number of polymer chains	1
Total formula weight	13955.89
Authors	Runcie, A.C.,Chan, K.-H.,Ciulli, A. (deposition date: 2017-05-23, release date: 2018-02-14, Last modification date: 2024-01-17)
Primary citation	Runcie, A.C.,Zengerle, M.,Chan, K.H.,Testa, A.,van Beurden, L.,Baud, M.G.J.,Epemolu, O.,Ellis, L.C.J.,Read, K.D.,Coulthard, V.,Brien, A.,Ciulli, A. Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chem Sci, 9:2452-2468, 2018 Cited by PubMed: 29732121 DOI: 10.1039/c7sc02536j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation