7L99

Crystal structure of BRDT bromodomain 2 in complex with CDD-1302

Summary for 7L99

Entry DOI	10.2210/pdb7l99/pdb
Descriptor	Bromodomain testis-specific protein, N-[3-(acetylamino)-4-methylphenyl]-3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carboxamide, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), ... (4 entities in total)
Functional Keywords	inhibitor complex, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	66266.97
Authors	Sharma, R.,Yu, Z.,Ku, A.F.,Anglin, J.L.,Ucisik, M.N.,Faver, J.C.,Sankaran, B.,Kim, C.,Matzuk, M.M. (deposition date: 2021-01-03, release date: 2021-06-30, Last modification date: 2023-10-18)
Primary citation	Yu, Z.,Ku, A.F.,Anglin, J.L.,Sharma, R.,Ucisik, M.N.,Faver, J.C.,Li, F.,Nyshadham, P.,Simmons, N.,Sharma, K.L.,Nagarajan, S.,Riehle, K.,Kaur, G.,Sankaran, B.,Storl-Desmond, M.,Palmer, S.S.,Young, D.W.,Kim, C.,Matzuk, M.M. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33637650 DOI: 10.1073/pnas.2021102118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation