PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

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6TBN	Crystal structure of CIAO1-CIAO2B CIA core complex 分子名称: MIP18 family protein galla-2, Probable cytosolic iron-sulfur protein assembly protein Ciao1, SODIUM ION 著者 Kassube, S.A, Thoma, N.H. 登録日 2019-11-01 公開日 2020-07-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
6TC0	Crystal structure of MMS19-CIAO1-CIAO2B CIA targeting complex 分子名称: MIP18 family protein galla-2, MMS19 nucleotide excision repair protein homolog, Probable cytosolic iron-sulfur protein assembly protein Ciao1 著者 Kassube, S.A, Thoma, N.H. 登録日 2019-11-04 公開日 2020-07-29 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
6U4Y	Crystal Structure of an EZH2-EED Complex in an Oligomeric State 分子名称: Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Jiao, L, Liu, X. 登録日 2019-08-26 公開日 2020-07-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 A partially disordered region connects gene repression and activation functions of EZH2. Proc.Natl.Acad.Sci.USA, 117, 2020
6U62	Raptor-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Rogala, K.B, Sabatini, D.M. 登録日 2019-08-29 公開日 2019-10-30 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. 登録日 2019-09-26 公開日 2020-12-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
6V0N	PRMT5 bound to PBM peptide from Riok1 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ... 著者 McMIllan, B.J, Raymond, D.D. 登録日 2019-11-19 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6UXY	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 分子名称: (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... 著者 Palte, R.L, Schneider, S.E. 登録日 2019-11-08 公開日 2020-08-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V4U	Cryo-EM structure of SMCR8-C9orf72-WDR41 complex 分子名称: Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 著者 Su, M.Y, Hurley, J.H. 登録日 2019-12-01 公開日 2020-09-02 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature, 585, 2020
6V0O	PRMT5 bound to the PBM peptide from pICln 分子名称: ACETYL GROUP, Methylosome protein 50, PBM peptide, ... 著者 McMillan, B.J, Raymond, D.D. 登録日 2019-11-19 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6UXX	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a 分子名称: (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Palte, R.L, Schneider, S.E. 登録日 2019-11-08 公開日 2020-08-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V0P	PRMT5 complex bound to covalent PBM inhibitor BRD6711 分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ... 著者 McMillan, B.J, McKinney, D.C. 登録日 2019-11-19 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
6TLJ	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Alfieri, C, Barford, D. 登録日 2019-12-02 公開日 2020-02-19 最終更新日 2020-06-17 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
6VYC	Crystal structure of WD-repeat domain of human WDR91 分子名称: UNKNOWN ATOM OR ION, WD repeat-containing protein 91 著者 Halabelian, L, Hutchinson, A, Li, Y, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2020-02-26 公開日 2020-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
8JKB	Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits 分子名称: BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 著者 Zheng, S, Jiang, W, Wang, W, Kong, Y. 登録日 2023-06-01 公開日 2023-07-26 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase. Sci Adv, 9, 2023
8JHB	FZD6 Gs complex 分子名称: Frizzled-6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, F, Zhang, Z. 登録日 2023-05-23 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
8JHI	FZD3-Gs complex 分子名称: Frizzled-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, F, Zhang, Z. 登録日 2023-05-23 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
8J9N	Gq bound FZD1 in ligand-free state 分子名称: Frizzled-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Lin, X, Xu, F. 登録日 2023-05-04 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
8JBH	Substance P bound to active human neurokinin 3 receptor in complex with Gq 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq subunit alpha (G324), ... 著者 Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. 登録日 2023-05-08 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
8JBG	Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq (G324), ... 著者 Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. 登録日 2023-05-08 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
6ZG6	COPII on membranes, outer coat vertex 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-18 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (12 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
6ZG5	COPII on membranes, outer coat right-handed rod, class1 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-18 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (40 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
6ZL0	COPII on membranes, outer coat left-handed rod 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-30 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (40 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
6ZRD	STRUCTURE OF THE HUMAN RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines 分子名称: 1,3,5-trimethylbenzene, Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1 著者 Vetter, I.R, Porfetye, A.T. 登録日 2020-07-13 公開日 2020-12-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48. Angew.Chem.Int.Ed.Engl., 60, 2021
6ZYX	Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila 分子名称: Dynein heavy chain, outer arm protein, Dynein intermediate chain 2, ... 著者 Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. 登録日 2020-08-03 公開日 2021-01-20 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
7AD3	Class D GPCR Ste2 dimer coupled to two G proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-factor mating pheromone, CHOLESTEROL HEMISUCCINATE, ... 著者 Velazhahan, V, Tate, C. 登録日 2020-09-14 公開日 2020-12-09 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the class D GPCR Ste2 dimer coupled to two G proteins. Nature, 589, 2021

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