8JBH

Substance P bound to active human neurokinin 3 receptor in complex with Gq

This is a non-PDB format compatible entry.

Summary for 8JBH

• Entry DOI: 10.2210/pdb8jbh/pdb
• EMDB information: 36146
• Descriptor: NK3R-pFastbac1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16 nanobody, ... (6 entities in total)
• Functional Keywords: g protein coupled receptor, neurokinin, cryo-em, peptide agonists, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 282759.93

Authors

Sun, W.J.,Yang, F.,Zhang, H.H.,Yuan, Q.N.,Yin, W.C.,Shi, P.,Eric, X.,Tian, C.L. (deposition date: 2023-05-08, release date: 2024-02-07)

• Primary citation: Sun, W.,Yang, F.,Zhang, H.,Yuan, Q.,Ling, S.,Wang, Y.,Lv, P.,Li, Z.,Luo, Y.,Liu, D.,Yin, W.,Shi, P.,Xu, H.E.,Tian, C.; Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists.; Cell Discov, 9:66-66, 2023; PubMed: 37391393; DOI: 10.1038/s41421-023-00564-w

Experimental method

ELECTRON MICROSCOPY (2.9 Å)