8JKB

Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits

Summary for 8JKB

• Entry DOI: 10.2210/pdb8jkb/pdb
• EMDB information: 36367
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, BTB/POZ domain-containing protein KCTD5 (3 entities in total)
• Functional Keywords: ubiquitination, gpcr signaling, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 15
• Total formula weight: 410490.58

Authors

Zheng, S.,Jiang, W.,Wang, W.,Kong, Y. (deposition date: 2023-06-01, release date: 2023-07-26)

• Primary citation: Jiang, W.,Wang, W.,Kong, Y.,Zheng, S.; Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.; Sci Adv, 9:eadg8369-eadg8369, 2023; PubMed: 37450587; DOI: 10.1126/sciadv.adg8369

Experimental method

ELECTRON MICROSCOPY (3.27 Å)