8JKB

Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044877	molecular_function	protein-containing complex binding
A	0051260	biological_process	protein homooligomerization
A	0097602	molecular_function	cullin family protein binding
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B	0007265	biological_process	Ras protein signal transduction
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0051020	molecular_function	GTPase binding
B	0070062	cellular_component	extracellular exosome
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
B	1903561	cellular_component	extracellular vesicle
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044877	molecular_function	protein-containing complex binding
C	0051260	biological_process	protein homooligomerization
C	0097602	molecular_function	cullin family protein binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0044877	molecular_function	protein-containing complex binding
D	0051260	biological_process	protein homooligomerization
D	0097602	molecular_function	cullin family protein binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044877	molecular_function	protein-containing complex binding
E	0051260	biological_process	protein homooligomerization
E	0097602	molecular_function	cullin family protein binding
F	0001750	cellular_component	photoreceptor outer segment
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0005834	cellular_component	heterotrimeric G-protein complex
F	0005886	cellular_component	plasma membrane
F	0007165	biological_process	signal transduction
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
F	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
F	0007265	biological_process	Ras protein signal transduction
F	0016020	cellular_component	membrane
F	0030159	molecular_function	signaling receptor complex adaptor activity
F	0044877	molecular_function	protein-containing complex binding
F	0045202	cellular_component	synapse
F	0051020	molecular_function	GTPase binding
F	0070062	cellular_component	extracellular exosome
F	0071380	biological_process	cellular response to prostaglandin E stimulus
F	0071870	biological_process	cellular response to catecholamine stimulus
F	0097381	cellular_component	photoreceptor disc membrane
F	1903561	cellular_component	extracellular vesicle
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0045202	cellular_component	synapse
G	0070062	cellular_component	extracellular exosome
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0042802	molecular_function	identical protein binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0044877	molecular_function	protein-containing complex binding
H	0051260	biological_process	protein homooligomerization
H	0097602	molecular_function	cullin family protein binding
I	0001750	cellular_component	photoreceptor outer segment
I	0003924	molecular_function	GTPase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005765	cellular_component	lysosomal membrane
I	0005829	cellular_component	cytosol
I	0005834	cellular_component	heterotrimeric G-protein complex
I	0005886	cellular_component	plasma membrane
I	0007165	biological_process	signal transduction
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
I	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
I	0007265	biological_process	Ras protein signal transduction
I	0016020	cellular_component	membrane
I	0030159	molecular_function	signaling receptor complex adaptor activity
I	0044877	molecular_function	protein-containing complex binding
I	0045202	cellular_component	synapse
I	0051020	molecular_function	GTPase binding
I	0070062	cellular_component	extracellular exosome
I	0071380	biological_process	cellular response to prostaglandin E stimulus
I	0071870	biological_process	cellular response to catecholamine stimulus
I	0097381	cellular_component	photoreceptor disc membrane
I	1903561	cellular_component	extracellular vesicle
J	0001750	cellular_component	photoreceptor outer segment
J	0003924	molecular_function	GTPase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0005834	cellular_component	heterotrimeric G-protein complex
J	0005886	cellular_component	plasma membrane
J	0007165	biological_process	signal transduction
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
J	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
J	0007265	biological_process	Ras protein signal transduction
J	0016020	cellular_component	membrane
J	0030159	molecular_function	signaling receptor complex adaptor activity
J	0044877	molecular_function	protein-containing complex binding
J	0045202	cellular_component	synapse
J	0051020	molecular_function	GTPase binding
J	0070062	cellular_component	extracellular exosome
J	0071380	biological_process	cellular response to prostaglandin E stimulus
J	0071870	biological_process	cellular response to catecholamine stimulus
J	0097381	cellular_component	photoreceptor disc membrane
J	1903561	cellular_component	extracellular vesicle
K	0001750	cellular_component	photoreceptor outer segment
K	0003924	molecular_function	GTPase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0005834	cellular_component	heterotrimeric G-protein complex
K	0005886	cellular_component	plasma membrane
K	0007165	biological_process	signal transduction
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
K	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
K	0007265	biological_process	Ras protein signal transduction
K	0016020	cellular_component	membrane
K	0030159	molecular_function	signaling receptor complex adaptor activity
K	0044877	molecular_function	protein-containing complex binding
K	0045202	cellular_component	synapse
K	0051020	molecular_function	GTPase binding
K	0070062	cellular_component	extracellular exosome
K	0071380	biological_process	cellular response to prostaglandin E stimulus
K	0071870	biological_process	cellular response to catecholamine stimulus
K	0097381	cellular_component	photoreceptor disc membrane
K	1903561	cellular_component	extracellular vesicle
L	0005515	molecular_function	protein binding
L	0005834	cellular_component	heterotrimeric G-protein complex
L	0005886	cellular_component	plasma membrane
L	0007165	biological_process	signal transduction
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
L	0016020	cellular_component	membrane
L	0031681	molecular_function	G-protein beta-subunit binding
L	0045202	cellular_component	synapse
L	0070062	cellular_component	extracellular exosome
L	0071380	biological_process	cellular response to prostaglandin E stimulus
L	0071870	biological_process	cellular response to catecholamine stimulus
M	0005515	molecular_function	protein binding
M	0005834	cellular_component	heterotrimeric G-protein complex
M	0005886	cellular_component	plasma membrane
M	0007165	biological_process	signal transduction
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
M	0016020	cellular_component	membrane
M	0031681	molecular_function	G-protein beta-subunit binding
M	0045202	cellular_component	synapse
M	0070062	cellular_component	extracellular exosome
M	0071380	biological_process	cellular response to prostaglandin E stimulus
M	0071870	biological_process	cellular response to catecholamine stimulus
N	0005515	molecular_function	protein binding
N	0005834	cellular_component	heterotrimeric G-protein complex
N	0005886	cellular_component	plasma membrane
N	0007165	biological_process	signal transduction
N	0007186	biological_process	G protein-coupled receptor signaling pathway
N	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
N	0016020	cellular_component	membrane
N	0031681	molecular_function	G-protein beta-subunit binding
N	0045202	cellular_component	synapse
N	0070062	cellular_component	extracellular exosome
N	0071380	biological_process	cellular response to prostaglandin E stimulus
N	0071870	biological_process	cellular response to catecholamine stimulus
O	0005515	molecular_function	protein binding
O	0005834	cellular_component	heterotrimeric G-protein complex
O	0005886	cellular_component	plasma membrane
O	0007165	biological_process	signal transduction
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
O	0016020	cellular_component	membrane
O	0031681	molecular_function	G-protein beta-subunit binding
O	0045202	cellular_component	synapse
O	0070062	cellular_component	extracellular exosome
O	0071380	biological_process	cellular response to prostaglandin E stimulus
O	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	225
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	200
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	205
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	215
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	205
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	150
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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