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6TZW
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BU of 6tzw by Molmil
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility
分子名称: CALCIUM ION, Protein bicaudal D
著者Cui, H, Solmaz, S.R.
登録日2019-08-13
公開日2020-05-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility.
Traffic, 21, 2020
8H7J
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BU of 8h7j by Molmil
The crystal structure of CD163 SRCR5-9
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Scavenger receptor cysteine-rich type 1 protein M130, ...
著者Luo, Z.P, Li, R, Ma, H.F.
登録日2022-10-20
公開日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of CD163 SRCR5-9
To Be Published
6TY5
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BU of 6ty5 by Molmil
Crystal structure of human TLR8 in complex with Compound 11
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl)furo[3,2-c]pyridin-4-one, Toll-like receptor 8, ...
著者Faller, M, Zink, F.
登録日2020-01-15
公開日2020-08-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.793 Å)
主引用文献Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
J.Med.Chem., 63, 2020
6OZ9
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BU of 6oz9 by Molmil
Ebola virus glycoprotein in complex with EBOV-520 Fab
分子名称: EBOV-520 Fab heavy chain, EBOV-520 Fab light chain, Envelope glycoprotein, ...
著者Milligan, J.C, Altman, P.X, Hui, S, Hastie, K.M, Gilchuk, P, Crowe, J.E, Saphire, E.O.
登録日2019-05-15
公開日2020-03-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.462 Å)
主引用文献Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
6P50
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BU of 6p50 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ...
著者Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
登録日2019-05-29
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6PJU
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BU of 6pju by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6P69
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BU of 6p69 by Molmil
Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11.
分子名称: 1,2-ETHANEDIOL, Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide, ...
著者Larsen, N.A.
登録日2019-06-03
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献To be published
TBD
6PJR
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BU of 6pjr by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: CHLORIDE ION, Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6TYY
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BU of 6tyy by Molmil
Hedgehog autoprocessing mutant D46H
分子名称: Protein hedgehog
著者Li, H, Li, Z, Wang, C, Callahan, B.P.
登録日2019-08-09
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
J.Am.Chem.Soc., 141, 2019
6P91
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BU of 6p91 by Molmil
Structure of Lassa virus glycoprotein bound to Fab 18.5C
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 18.5C Antibody heavy chain, ...
著者Saphire, E.O, Hastie, K.M.
登録日2019-06-09
公開日2019-08-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
6PJA
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BU of 6pja by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-10-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ5
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BU of 6pj5 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-27
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
2IL3
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BU of 2il3 by Molmil
Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity
分子名称: Epsilon-class Glutathione S-transferase
著者Wang, Y, Hemingway, J, Ranson, H, Meehan, E.J, Chen, L.
登録日2006-10-02
公開日2007-10-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
J.Struct.Biol., 164, 2008
2IMK
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BU of 2imk by Molmil
Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity
分子名称: Epsilon-class Glutathione S-transferase, S-HEXYLGLUTATHIONE
著者Wang, Y, Hemingway, J, Ranson, H, Meehan, E.J, Chen, L.
登録日2006-10-02
公開日2007-10-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
J.Struct.Biol., 164, 2008
6PJ9
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BU of 6pj9 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6P14
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BU of 6p14 by Molmil
Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, ACETATE ION, ...
著者Pisa, R, Cupido, T, Kapoor, T.M.
登録日2019-05-17
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.93001127 Å)
主引用文献Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6P68
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BU of 6p68 by Molmil
Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.
分子名称: Fibroblast growth factor receptor 1, N-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1H-pyrazol-4-yl}prop-2-enamide, SULFATE ION
著者Larsen, N.A.
登録日2019-06-03
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献To be published
To Be Published
6P13
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BU of 6p13 by Molmil
Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form A)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, SULFATE ION, ...
著者Pisa, R, Cupido, T, Kapoor, T.M.
登録日2019-05-17
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6PGI
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BU of 6pgi by Molmil
Asymmetric functions of a binuclear metal cluster within the transport pathway of the ZIP transition metal transporters
分子名称: BbZIP, CADMIUM ION
著者Zhang, T, Sui, D, Zhang, C, Logan, T, Hu, J.
登録日2019-06-24
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.
Faseb J., 34, 2020
8I0I
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BU of 8i0i by Molmil
dmCTPS with dATP dUTP dGTP and DON
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CTP synthase, DEOXYURIDINE-5'-TRIPHOSPHATE, ...
著者Guo, C.J, Liu, J.L.
登録日2023-01-11
公開日2024-07-24
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of bifunctional CTP/dCTP synthase
Biorxiv, 2023
6PJ7
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BU of 6pj7 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJQ
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BU of 6pjq by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6P95
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BU of 6p95 by Molmil
Structure of Lassa virus glycoprotein in complex with Fab 25.6A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Saphire, E.O, Hastie, K.M.
登録日2019-06-09
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
8JE4
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BU of 8je4 by Molmil
Crystal structure of LimF prenyltransferase (H239G/W273T mutant) bound with the thiodiphosphate moiety of farnesyl S-thiolodiphosphate (FSPP)
分子名称: MAGNESIUM ION, TRIHYDROGEN THIODIPHOSPHATE, prenyltransferase, ...
著者Hamada, K, Oguni, A, Zhang, Y, Satake, M, Goto, Y, Suga, H, Ogata, K, Sengoku, T.
登録日2023-05-15
公開日2023-11-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases.
J.Am.Chem.Soc., 145, 2023
6PJ8
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BU of 6pj8 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
分子名称: Peptide aldehyde inhibitor, Rhomboid protease GlpG
著者Urban, S, Cho, S.
登録日2019-06-28
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019

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