6P14

Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B)

Summary for 6P14

Entry DOI	10.2210/pdb6p14/pdb
Descriptor	Spastin, (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION, ... (6 entities in total)
Functional Keywords	inhibitor, complex, aaa protein, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	1
Total formula weight	35066.82
Authors	Pisa, R.,Cupido, T.,Kapoor, T.M. (deposition date: 2019-05-17, release date: 2019-07-24, Last modification date: 2023-10-11)
Primary citation	Pisa, R.,Cupido, T.,Steinman, J.B.,Jones, N.H.,Kapoor, T.M. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26:1263-, 2019 Cited by PubMed: 31257183 DOI: 10.1016/j.chembiol.2019.06.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93001125684 Å)

Structure validation