6P14
Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Spastin | polymer | 314 | 34291.0 | 1 | UniProt (Q8I0P1) Pfam (PF00004) Pfam (PF17862) Pfam (PF09336) In PDB | Drosophila melanogaster (Fruit fly) | D-Spastin,Dm-Spastin,Dspastin |
| 2 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | A | 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide | non-polymer | 384.4 | 1 | Chemie (NKY) | |||
| 5 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A: 445 - 758 (UniProt: Q8I0P1)
| PDB | External Database | Details |
|---|---|---|
| Ala 692 | Thr 692 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34291.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 775.8 | |
| All* | Total formula weight | 35066.8 |
