6P68

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.

Summary for 6P68

DescriptorFibroblast growth factor receptor 1, N-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1H-pyrazol-4-yl}prop-2-enamide, SULFATE ION, ... (4 entities in total)
Functional Keywordstransferase-transfer complex, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight107072.2
Authors
Larsen, N.A. (deposition date: 2019-06-03, release date: 2019-06-19)
Primary citation
Larsen, N.A.
To be published
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2977 1.9% 6.1% 8.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution