6P68

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005007	molecular_function	fibroblast growth factor receptor activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue O1Y A 801

Chain	Residue
A	LEU484
A	GLU571
A	LEU630
A	ALA640
A	ASP641
A	PHE642
A	LEU494
A	ALA512
A	LYS514
A	GLU531
A	MET535
A	GLU562
A	CYS563
A	ALA564

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 802

Chain	Residue
A	ARG470
A	TRP471
A	LEU548
A	GLY549

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 802

Chain	Residue
B	ARG470
B	TRP471
B	GLU472
B	LEU548

---

site_id	AC4
Number of Residues	15
Details	binding site for Di-peptide O1Y B 801 and CYS B 563

Chain	Residue
B	LEU484
B	VAL492
B	LEU494
B	LYS510
B	ALA512
B	LYS514
B	GLU531
B	MET535
B	ILE545
B	VAL561
B	GLU562
B	ALA564
B	SER565
B	ALA640
B	ASP641

---

site_id	AC5
Number of Residues	16
Details	binding site for Di-peptide O1Y C 801 and CYS C 563

Chain	Residue
C	LEU484
C	VAL492
C	LEU494
C	LYS510
C	ALA512
C	LYS514
C	GLU531
C	MET535
C	ILE545
C	VAL561
C	GLU562
C	ALA564
C	SER565
C	LEU630
C	ALA640
C	ASP641

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897

Chain	Residue	Details
A	ASP623
B	ASP623
C	ASP623

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING:

Chain	Residue	Details
A	LEU484
B	ASN568
B	ARG627
B	ASP641
C	LEU484
C	LYS514
C	GLU562
C	ASN568
C	ARG627
C	ASP641
A	LYS514
A	GLU562
A	ASN568
A	ARG627
A	ASP641
B	LEU484
B	LYS514
B	GLU562

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR463
A	TYR583
A	TYR585
B	TYR463
B	TYR583
B	TYR585
C	TYR463
C	TYR583
C	TYR585

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR653
A	TYR654
B	TYR653
B	TYR654
C	TYR653
C	TYR654

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR730
B	TYR730
C	TYR730

---