6P68
Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fibroblast growth factor receptor 1 | polymer | 309 | 35075.3 | 3 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | D, F, H (A, B, C) | N-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1H-pyrazol-4-yl}prop-2-enamide | non-polymer | 551.4 | 3 | Chemie (O1Y) | |||
| 3 | E, G (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | I, J, K (A, B, C) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 457 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Cys 563 | Tyr 563 | engineered mutation |
| Ser 584 | Cys 584 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 105225.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1846.3 | |
| All* | Total formula weight | 107072.2 |
