6P69

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11.

Summary for 6P69

Related6P68
DescriptorFibroblast growth factor receptor 1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsfgfr, inhibitor complex, covalent inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight71912.14
Authors
Larsen, N.A. (deposition date: 2019-06-03, release date: 2019-06-19)
Primary citation
Prajapati, S.
To be published
TBD,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2462 0.5% 5.0% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution