PDB: 36667 件ウェブページステータス検索Chemie searchBIRD

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7OUB	High resolution structure of Alpha-1-acid glycoprotein bound to potent anti-tumour compound UCN-01 分子名称: 7-HYDROXYSTAUROSPORINE, Alpha-1-acid glycoprotein 2 著者 Landin, E.J.B, Williams, C, Crump, M.P. 登録日 2021-06-11 公開日 2021-12-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 The structural basis for high affinity binding of alpha 1-acid glycoprotein to the potent antitumor compound UCN-01. J.Biol.Chem., 297, 2021
7N7X	Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution 分子名称: Orladeyo, PHOSPHATE ION, Plasma kallikrein light chain 著者 Krishnan, R, Yarlagadda, B.S, Kotian, P, Polach, K.J, Zhang, W. 登録日 2021-06-11 公開日 2021-09-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE). J.Med.Chem., 64, 2021
7F2O	Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein 分子名称: ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG, B2 bradykinin receptor, G subunit q (Gi1-Gq chimeric), ... 著者 Yin, Y, Jiang, Y. 登録日 2021-06-11 公開日 2021-10-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nat.Struct.Mol.Biol., 28, 2021
7OTI	Structure of ABCB1/P-glycoprotein in apo state 分子名称: Multidrug resistance protein 1A 著者 Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
7OTX	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-257 分子名称: (S)-2-((3-(6-amino-9H-purin-9-yl)propyl)amino)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTK	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-233 分子名称: (2~{R})-2-[2-(6-aminopurin-9-yl)ethylamino]-3-phosphono-propanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTG	Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor 分子名称: Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 著者 Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (5.4 Å) 主引用文献 Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
7OTN	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-247 分子名称: (S)-2-((2-(6-amino-9H-purin-9-yl)ethyl)amino)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTZ	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-259 分子名称: (S)-2-(2-(6-amino-9H-purin-9-yl)ethoxy)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-10 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTC	Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B 分子名称: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ... 著者 Wieland, M, Koller, T.O, Wilson, D.N. 登録日 2021-06-10 公開日 2022-05-11 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation. Proc.Natl.Acad.Sci.USA, 119, 2022
7F26	Crystal structure of lysozyme 分子名称: Lysozyme C 著者 Liang, M. 登録日 2021-06-10 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Novel combined crystallization plate for high-throughput crystal screening and in situ data collection at a crystallography beamline. Acta Crystallogr.,Sect.F, 77, 2021
7F2F	The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. 分子名称: DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7 著者 Gui, W. 登録日 2021-06-10 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 77, 2021
7F24	Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex without Nb35 分子名称: D(1A) dopamine receptor, GUANOSINE-5'-TRIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xiao, T, Zheng, S. 登録日 2021-06-10 公開日 2022-06-15 最終更新日 2022-07-13 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Structural insights into G protein activation by D1 dopamine receptor. Sci Adv, 8, 2022
7F23	Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex with Nb35 分子名称: D(1A) dopamine receptor, GUANOSINE-5'-TRIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xiao, T, Zheng, S. 登録日 2021-06-10 公開日 2022-06-15 最終更新日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Structural insights into G protein activation by D1 dopamine receptor. Sci Adv, 8, 2022
7F1Z	Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex without Nb35 分子名称: D(1A) dopamine receptor, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xiao, T, Zheng, S. 登録日 2021-06-10 公開日 2022-06-15 最終更新日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Structural insights into G protein activation by D1 dopamine receptor. Sci Adv, 8, 2022
7OT6	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND inhibitor RMC-282 分子名称: (R)-N-(1-(6-amino-9H-purin-9-yl)propan-2-yl)-N-(2-phosphonoethyl)glycine, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-09 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OTA	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-230 分子名称: ((2-(6-amino-9H-purin-9-yl)ethyl)-L-seryl)phosphoramidic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Martinez, S.E, Singh, A.K, Gu, W, Das, K. 登録日 2021-06-09 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design. Eur.J.Med.Chem., 225, 2021
7OSM	Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands 分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0, ... 著者 Djumagulov, M, Jenner, L, Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. 登録日 2021-06-09 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Accuracy mechanism of eukaryotic ribosome translocation. Nature, 600, 2021
7N6T	Crystal structure of inhibitor-free HIV-1 PRS17 revertant mutant PRS17 V48G 分子名称: Protease 著者 Burnaman, S.H, Wang, Y.-F, Weber, I.T. 登録日 2021-06-09 公開日 2021-09-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17. J.Mol.Graph.Model., 108, 2021
7N6V	Crystal structure of HIV-1 Protease multiple mutants PRS17 with Revertant mutation V48G bound to inhibitor Amprenavir 分子名称: GLYCEROL, Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER 著者 Burnaman, S.H, Wang, Y.-F, Weber, I.T. 登録日 2021-06-09 公開日 2021-09-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17. J.Mol.Graph.Model., 108, 2021
7N6X	Crystal structure of HIV-1 Protease multiple mutants PRS17 bound to inhibitor Amprenavir 分子名称: Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER 著者 Burnaman, S.H, Wang, Y.-F, Weber, I.T. 登録日 2021-06-09 公開日 2021-09-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17. J.Mol.Graph.Model., 108, 2021
7F1R	Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi 分子名称: C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
7F1T	Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a 分子名称: C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
7F1S	Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi 分子名称: C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
7F1Q	Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi 分子名称: C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021

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