7OUB

High resolution structure of Alpha-1-acid glycoprotein bound to potent anti-tumour compound UCN-01

Summary for 7OUB

• Entry DOI: 10.2210/pdb7oub/pdb
• Descriptor: Alpha-1-acid glycoprotein 2, 7-HYDROXYSTAUROSPORINE (3 entities in total)
• Functional Keywords: agp2, orm2, lipocalin, complex, alpha-1-acid glycoprotein, ucn-01, protein transport
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23026.76

Authors

Landin, E.J.B.,Williams, C.,Crump, M.P. (deposition date: 2021-06-11, release date: 2021-12-01, Last modification date: 2024-01-31)

• Primary citation: Landin, E.J.B.,Williams, C.,Ryan, S.A.,Bochel, A.,Akter, N.,Redfield, C.,Sessions, R.B.,Dedi, N.,Taylor, R.J.,Crump, M.P.; The structural basis for high affinity binding of alpha 1-acid glycoprotein to the potent antitumor compound UCN-01.; J.Biol.Chem., 297:101392-101392, 2021; PubMed: 34758357; DOI: 10.1016/j.jbc.2021.101392

Experimental method

X-RAY DIFFRACTION (1.82 Å)