7OUB

High resolution structure of Alpha-1-acid glycoprotein bound to potent anti-tumour compound UCN-01

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Alpha-1-acid glycoprotein 2	polymer	191	22544.2	1	UniProt (P19652) Pfam (PF00061)	Homo sapiens (Human)	AGP 2,Orosomucoid-2,OMD 2
2	B (B)	7-HYDROXYSTAUROSPORINE	non-polymer		482.5	1	Chemie (UCN) PubChem (44352971) PubChem (44352972) PubChem (46936262) PubChem (49868158) PubChem (50909235) PubChem (56603728) PubChem (59476526) PubChem (73265332) PubChem (59728753) PubChem (72271) PubChem (4616292) PubChem (71102317) PubChem (3078519) PubChem (92340205) PubChem (5459175) PubChem (9956895) PubChem (98104822) PubChem (98104824) PubChem (9548014) PubChem (146156682) PubChem (126969762) PubChem (134433893) PubChem (143541970) PubChem (145705955) PubChem (156588835) PubChem (162907950) PubChem (162907951) PubChem (162907952) PubChem (166890143)
3	C (B)	water	water		18.0	223	Chemie (HOH)

Sequence modifications

B: 1 - 172 (UniProt: P19652)

PDB	External Database	Details
Met -18	-	initiating methionine
Ala -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag
Arg 149	Cys 167	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22544.2
Non-Polymers*	Number of molecules	1
	Total formula weight	482.5
All*	Total formula weight	23026.8

*Water molecules are not included.