7OUB

High resolution structure of Alpha-1-acid glycoprotein bound to potent anti-tumour compound UCN-01

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Alpha-1-acid glycoprotein 2	polymer	191	22544.2	1	UniProt (P19652) Pfam (PF00061) In PDB	Homo sapiens (Human)	AGP 2,Orosomucoid-2,OMD 2
2	B	7-HYDROXYSTAUROSPORINE	non-polymer		482.5	1	Chemie (UCN)
3		water	water		18.0	223	Chemie (HOH)

Sequence modifications

B: 1 - 172 (UniProt: P19652)

PDB	External Database	Details
Met -18	-	initiating methionine
Ala -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag
Arg 149	Cys 167	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22544.2
Non-Polymers*	Number of molecules	1
	Total formula weight	482.5
All*	Total formula weight	23026.8

*Water molecules are not included.