7OTN

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-247

Summary for 7OTN

• Entry DOI: 10.2210/pdb7otn/pdb
• Related: 7OT6 7OTA 7OTK
• Descriptor: Reverse transcriptase/ribonuclease H, DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), ... (7 entities in total)
• Functional Keywords: reverse transcriptase, rt inhibitor complex, acyclic nucleoside phosphonate analog, rt-dna complex, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 258609.46

Authors

Martinez, S.E.,Singh, A.K.,Gu, W.,Das, K. (deposition date: 2021-06-10, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Gu, W.,Martinez, S.,Singh, A.K.,Nguyen, H.,Rozenski, J.,Schols, D.,Herdewijn, P.,Das, K.,De Jonghe, S.; Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design.; Eur.J.Med.Chem., 225:113785-113785, 2021; PubMed: 34425311; DOI: 10.1016/j.ejmech.2021.113785

Experimental method

X-RAY DIFFRACTION (3.4 Å)